Input dependent modulation of olfactory bulb activity by HDB GABAergic projections
Input dependent modulation of olfactory bulb activity by HDB GABAergic projections
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DOI：
10.1038/s41598-020-67276-z
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发表时间：
2020-07-01
影响因子：
4.6
通讯作者：
Rothermel, Markus
中科院分区：
文献类型：
--
作者：
Boehm, Erik;Brunert, Daniela;Rothermel, Markus
基底前脑中枢电路的调节与活跃的感觉、注意和学习有关。虽然胆碱能调节已被广泛研究，但非胆碱能基底前脑亚群对感觉加工的影响仍不清楚。在这里，我们直接比较了两个主要的基底前脑亚群对早期感觉处理区域主要神经元活动的光遗传学操作的影响，即嗅球中的二尖瓣/簇状细胞（MTCs）。与持续增加MTC放电的胆碱能投射相反，从基底前脑到嗅球的gaba能纤维的激活导致了不同的调制效应：自发MTC活动主要被抑制，而气味诱发的放电主要被增强。此外，嗅探触发的平均结果显示，最大嗅探诱发的放电幅度增强，而最大嗅探期以外的放电速率受到抑制。这些发现表明，gaba能神经调节以双峰、感觉输入依赖的方式影响MTC放电，这表明gaba能基底前脑调节可能是注意介导的感觉信息向大脑过滤的重要因素。
Basal forebrain modulation of central circuits is associated with active sensation, attention, and learning. While cholinergic modulations have been studied extensively the effect of non-cholinergic basal forebrain subpopulations on sensory processing remains largely unclear. Here, we directly compare optogenetic manipulation effects of two major basal forebrain subpopulations on principal neuron activity in an early sensory processing area, i.e. mitral/tufted cells (MTCs) in the olfactory bulb. In contrast to cholinergic projections, which consistently increased MTC firing, activation of GABAergic fibers from basal forebrain to the olfactory bulb leads to differential modulation effects: while spontaneous MTC activity is mainly inhibited, odor-evoked firing is predominantly enhanced. Moreover, sniff-triggered averages revealed an enhancement of maximal sniff evoked firing amplitude and an inhibition of firing rates outside the maximal sniff phase. These findings demonstrate that GABAergic neuromodulation affects MTC firing in a bimodal, sensory-input dependent way, suggesting that GABAergic basal forebrain modulation could be an important factor in attention mediated filtering of sensory information to the brain.