mirAct: a web tool for evaluating microRNA activity based on gene expression data.
mirAct: a web tool for evaluating microRNA activity based on gene expression data.
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mirAct:基于基因表达数据评估 microRNA 活性的网络工具
DOI:
10.1093/nar/gkr351
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发表时间:
2011-07
影响因子:
14.9
通讯作者:
Wu J
中科院分区:
文献类型:
--
作者:
Liang Z;Zhou H;He Z;Zheng H;Wu J
MicroRNAs (miRNAs) are critical regulators in the complex cellular networks. The mirAct web server (http://sysbio.ustc.edu.cn/software/mirAct) is a tool designed to investigate miRNA activity based on gene-expression data by using the negative regulation relationship between miRNAs and their target genes. mirAct supports multiple-class data and enables clustering analysis based on computationally determined miRNA activity. Here, we describe the framework of mirAct, demonstrate its performance by comparing with other similar programs and exemplify its applications using case studies.
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