Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child.
Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child.
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通过来自自闭症儿童的抗体证明血清素结合位点的种间和种内差异。
DOI：
10.1073/pnas.82.2.612
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发表时间：
1985
影响因子：
11.1
通讯作者：
Ciaranello,RD
中科院分区：
文献类型：
--
作者：
Todd,RD;Ciaranello,RD
Serotonin (5-HT) binding sites from bovine and rat cerebral cortex membranes share pharmacological properties that allow both to be subclassified by the same criteria. We show here that [3H]5-HT binding sites from human cortex also possess pharmacological properties that follow the same subclassification scheme as for bovine and rat cortex. In addition, we show that solubilized 5-HT1 and 5-HT3 sites from all three species have an s20,w value of 3.4. Despite these similar pharmacological and physical characteristics, we can demonstrate antigenic differences between receptor types and species. Human 5-HT1A sites can be distinguished from human 5-HT1B, 5-HT2, and 5-HT3 sites and from equivalent sites in rat and bovine cortex. The anti-human 5-HT1A antibodies were discovered in the blood of an autistic child and may have clinical or etiologic significance for this disorder.
