Effects of olanzapine, risperidone and haloperidol on sleep after a single oral morning dose in healthy volunteers
Effects of olanzapine, risperidone and haloperidol on sleep after a single oral morning dose in healthy volunteers
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DOI：
10.1007/s00213-006-0633-7
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发表时间：
2007-03-01
影响因子：
3.4
通讯作者：
Barbanoj, Manuel J.
中科院分区：
文献类型：
--
作者：
Gimenez, Sandra;Clos, Susana;Barbanoj, Manuel J.
目的比较典型和非典型抗精神病药物对睡眠活动和主观睡眠质量的影响。采用随机、随机、双盲、安慰剂对照、四期交叉临床试验，评价积极治疗对客观和主观睡眠变量的影响。设置睡眠实验室评价。受试者20名健康青年志愿者，男女。干预措施单一早晨口服奥氮平5 mg、利培酮1 mg、氟哌啶醇3 mg和安慰剂。测量和结果评估5个多导睡眠图夜晚：一个对照夜和一个干预后。奥氮平治疗后患者的总睡眠时间、睡眠效率、慢波睡眠(SWS)和快速眼动睡眠(REM)睡眠明显增加，觉醒时间明显减少。利培酮治疗后觉醒时间、快速眼动睡眠和阶段转移减少，阶段2增加。氟哌啶醇只显示出增加睡眠效率、第二阶段和减少觉醒时间的趋势。在所有睡眠阶段，奥氮平在高于10 Hz的频率和低于5 Hz的频率范围内的功率密度降低；在第二和第四次非快速眼动(NREM)发作中，主轴频率活动(SFA)的动力学也降低。利培酮在NREM睡眠期和NREM睡眠期的3.6-10.8 Hz频率范围内均有增加。氟哌啶醇在NREM睡眠期和NREM睡眠期也有增加，但这些频率高于10 Hz，且第一个NREM睡眠期的SFA动力学增加。奥氮平治疗后仅主观睡眠质量有明显改善。结论抗精神病药物因其神经化学特征不同而表现出不同的睡眠改变。即使在睡前15小时给药，也能观察到这些变化。
Objectives To compare the effects of typical and atypical antipsychotic drugs on sleep activity and subjective sleep quality.Design Randomised, Randomised, double-blind, placebo-controlled, four-period cross-over, clinical trial was used to evaluate the effects of active treatments on objective and subjective sleep variables.Setting Sleep laboratory evaluation.Participants Twenty healthy young volunteers, both sexes.Interventions Single oral morning administrations of olanzapine 5 mg, risperidone 1 mg, haloperidol 3 mg and placebo.Measurements and results Five polysomnographic nights were evaluated: one control night and one after each intervention. Significant increase in total sleep time, sleep efficiency, slow wave sleep (SWS) and rapid eye movement (REM) sleep with decreases in wake time were observed after olanzapine. Decreases in wake time, REM sleep and stage shifts together with increases in stage 2 were obtained after risperidone. Haloperidol showed only a tendency to increase sleep efficiency and stage 2 and to decrease wake time. Olanzapine showed decreases in power density in frequencies higher than 10 Hz during all sleep stages and in frequencies lower than 5 Hz range in SWS; decreases in the dynamics of spindle frequency activity (SFA) in the second and fourth non-rapid eye movement (NREM) episodes were also obtained. Risperidone presented increases in the 3.6-10.8 Hz frequency range in NREM sleep stages and in stage 2. Haloperidol also showed increases in NREM sleep stages and in stage 2, but these were in frequencies higher than 10 Hz, with increases in the dynamics of SFA in the first NREM episode. Only a significant improvement in subjective sleep quality was observed after olanzapine.Conclusions Antipsychotics showed different sleep changes as their neurochemical profiles were distinct. These changes were observed even when the drug was administered 15 h before going to bed.