H.pylori Infection Alleviates Acute and Chronic Colitis with the Expansion of Regulatory B Cells in Mice
H.pylori Infection Alleviates Acute and Chronic Colitis with the Expansion of Regulatory B Cells in Mice
复制标题
幽门螺杆菌感染通过小鼠调节性 B 细胞的扩增缓解急性和慢性结肠炎
DOI：
10.1007/s10753-019-01022-0
复制
发表时间：
2019-10-01
期刊：
影响因子：
5.1
通讯作者：
Wang, Jingtong
中科院分区：
文献类型：
--
作者：
Li, Xia;Tan, Jiang;Wang, Jingtong
流行病学研究表明，幽门螺杆菌（H。pylori）感染和炎症性肠病（IBD）的发病率。我们的前期研究表明，H. pylori感染不仅局限于胃粘膜，而且影响肠粘膜免疫平衡。本研究用H. pylori SS 1感染，然后用3%葡聚糖硫酸钠（DSS）诱导结肠炎，以探讨调节性B细胞在H.幽门螺杆菌感染对急慢性结肠炎的影响急、慢性结肠炎组DAI评分和结肠组织学评分均明显降低，结肠长度缩短程度减轻，结肠黏膜中促炎细胞因子mRNA表达下调，CD 19 +IL-10+布雷格细胞百分比升高。pylori/DSS联合治疗组与DSS治疗组相比。我们的研究表明，H. pylori感染可减轻DSS诱导的急、慢性结肠炎，CD 19 +IL-10+布雷格细胞在H.幽门感染
Epidemiological studies showed that there was an inverse relationship between Helicobacter pylori (H. pylori) infection and the incidence of inflammatory bowel diseases (IBD). Our previous research indicated that the regulatory immune responses induced by H. pylori infection were not limited to gastric mucosa, and the balance of intestinal mucosal immunity was influenced. In this study, mice were infected with H. pylori SS1, and then colitis was induced by 3% dextran sulphate sodium (DSS), to investigate the role of the regulatory B cells in the effects of H. pylori infection on acute and chronic colitis. In acute and chronic colitis groups, DAI and colonic histological scores reduced significantly and colon length shorted less, the proinflammatory cytokines mRNA expression downregulated in colonic mucosa, and the percentages of CD19+IL-10+Breg cells were higher in the H. pylori/DSS co-treated groups compared with the DSS-treated groups. Our study suggests that H. pylori infection can alleviate the acute and chronic colitis induced by DSS, and CD19+IL-10+Breg cells may play a critical role in the alleviation of acute and chronic colitis following H. pylori infection.