Corrigendum to: "Parabens and measures of adiposity among adults and children from the U.S. general population: NHANES 2007-2014" [International Journal of Hygiene and Environmental Health 2018 May;221(4):652-660].
Corrigendum to: "Parabens and measures of adiposity among adults and children from the U.S. general population: NHANES 2007-2014" [International Journal of Hygiene and Environmental Health 2018 May;221(4):652-660].
复制标题
勘误：“对羟基苯甲酸酯和美国普通人群成人和儿童肥胖的测量：NHANES 2007-2014”[国际卫生与环境健康杂志，2018 年 5 月；221(4):652-660]。
DOI：
10.1016/j.ijheh.2019.05.010
复制
发表时间：
2019
影响因子：
6
通讯作者：
Boyle,Meleah
中科院分区：
文献类型：
--
作者：
Quirós-Alcalá,Lesliam;Buckley,JessieP;Boyle,Meleah
背景新兴的实验研究表明，对羟基苯甲酸酯可以通过改变微生物组或参与脂肪细胞分化的信号通路来影响新陈代谢。虽然人类接触对羟基苯甲酸酯的情况很普遍，但评估这些化学物质对肥胖测量的作用的流行病学研究却很少。 目的我们研究了对羟基苯甲酸酯与美国普通人群中成人和儿童肥胖测量的关联。 方法我们采用协变量调整线性和逻辑回归模型来检查四种对羟基苯甲酸酯（丁基-BP、乙基-EP、甲基-MP和对羟基苯甲酸丙酯-PP）的尿液生物标志物浓度与对羟基苯甲酸酯的测量之间的关联。参与国家健康和营养检查调查的 4730 名成人（2007-2014 年）和 1324 名儿童（2007-2012 年）的肥胖情况（肥胖；体重指数、BMI 或 BMI z 分数；以及腰围）。我们还评估了性别之间关联的异质性。结果我们通常观察到成人（BP、EP、MP、PP）和儿童（MP）的肥胖指标与对羟基苯甲酸酯生物标志物浓度之间存在显着的负相关。例如，MP 浓度每增加 10 倍，调整后的肥胖患病率比值比（95% 置信区间，CI）对于成人为 0.64（95% CI：0.55，0.73），对于儿童为 0.71（95% CI：0.52，0.95）。反向关联的强度通常随着对羟基苯甲酸酯暴露四分位数的增加而单调增加；总体而言，女性中的反向关联更为明显。当控制先前与肥胖测量相关的其他酚类化合物时，关联仍然存在。结论在这项肥胖测量和对羟基苯甲酸酯的横断面研究中，我们在美国成人和儿童的代表性样本中观察到一致的反向关联。需要进一步的研究来证实我们的发现，检查对羟基苯甲酸酯在脂肪组织中封存的潜在作用，并阐明对羟基苯甲酸酯改变代谢的机制。
BackgroundEmerging experimental studies suggest that parabens could affect metabolism by altering the microbiome or signaling pathways involved in adipocyte differentiation. While human exposure to parabens is widespread, epidemiologic studies assessing the role of these chemicals on adiposity measures are scarce.ObjectiveWe examined associations of parabens with adiposity measures among adults and children in the U.S. general population.MethodsWe conducted covariate-adjusted linear and logistic regression models to examine associations between urinary biomarker concentrations of four parabens (butyl-BP, ethyl-EP, methyl-MP, and propyl paraben-PP) and measures of adiposity (obesity; body mass index, BMI or BMI z-score; and waist circumference) among 4730 adults (2007–2014) and 1324 children (2007–2012), participating in the National Health and Nutrition Examination Survey. We also assessed heterogeneity of associations by gender.ResultsWe generally observed significant inverse associations between adiposity measures and paraben biomarker concentrations among adults (BP, EP, MP, PP) and children (MP). For example, adjusted prevalence odds ratios (95% confidence intervals, CI) for obesity per a ten-fold increase in MP concentrations were 0.64 (95% CI: 0.55, 0.73) for adults and 0.71(95% CI: 0.52, 0.95) for children. Strength of inverse associations typically increased monotonically with increasing paraben exposure quartiles; and, in general, inverse associations were more pronounced among females. Associations remained when controlling for other phenolic compounds previously linked with adiposity measures.ConclusionsIn this cross-sectional study of adiposity measures and parabens, we observed consistent inverse associations in a representative sample of U.S adults and children. Further studies are warranted to confirm our findings, examine the potential role of paraben sequestration in adipose tissue, and elucidate mechanisms by which parabens could alter metabolism.