Neuronal and astrocytic primary cilia in the mature brain.
Neuronal and astrocytic primary cilia in the mature brain.
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DOI：
10.1016/j.phrs.2018.10.002
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发表时间：
2018-11
影响因子：
9.3
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Sterpka A;Chen X
初级纤毛是基于微管的微小信号装置，调节多种生理功能，包括代谢和细胞分裂。初级纤毛的缺陷导致了人类无数的疾病，如肥胖和癌症。在成熟的大脑中，神经元和星形胶质细胞都含有单一的初级纤毛。虽然神经元初级纤毛不直接参与突触通讯，但其对肥胖和精神障碍的病理生理影响是公认的。而星形细胞原纤毛的研究相对滞后。目前，人们对它们在成熟大脑中的功能和分子途径知之甚少。与神经元不同，出生后的星形胶质细胞保留了细胞分裂的能力，并能对各种脑损伤（如癫痫、缺血、创伤性脑损伤和神经退行性β-淀粉样斑块）产生反应和增殖。由于初级纤毛来源于母体中心粒，因此星形胶质细胞的增殖必须与星形胶质细胞纤毛的拆除和纤毛形成协调进行。在这方面，神经元和星形细胞初级纤毛的功能、信号通路和结构动力学是根本不同的。在这里，我们讨论和比较目前对神经元和星形细胞初级纤毛的理解。
Primary cilia are tiny microtubule-based signaling devices that regulate a variety of physiological functions, including metabolism and cell division. Defects in primary cilia lead to a myriad of diseases in humans such as obesity and cancers. In the mature brain, both neurons and astrocytes contain a single primary cilium. Although neuronal primary cilia are not directly involved in synaptic communication, their pathophysiological impacts on obesity and mental disorders are well recognized. In contrast, research on astrocytic primary cilia lags far behind. Currently, little is known about their functions and molecular pathways in the mature brain. Unlike neurons, postnatal astrocytes retain the capacity of cell division and can become reactive and proliferate in response to various brain insults such as epilepsy, ischemia, traumatic brain injury, and neurodegenerative β-amyloid plaques. Since primary cilia derive from the mother centrioles, astrocyte proliferation must occur in coordination with the dismantling and ciliogenesis of astrocyte cilia. In this regard, the functions, signal pathways, and structural dynamics of neuronal and astrocytic primary cilia are fundamentally different. Here we discuss and compare the current understanding of neuronal and astrocytic primary cilia.
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DOI：
10.1073/pnas.1210192110
发表时间：
2013-05-07
影响因子：
11.1
作者：
Berbari, Nicolas F.;Pasek, Raymond C.;Yoder, Bradley K.
通讯作者：
Yoder, Bradley K.
影响因子：
4
作者：
Di Pietro, Chiara;Marazziti, Daniela;Tocchini-Valentini, Glauco P.
通讯作者：
Tocchini-Valentini, Glauco P.
影响因子：
3.7
作者：
Berbari NF;Malarkey EB;Yazdi SM;McNair AD;Kippe JM;Croyle MJ;Kraft TW;Yoder BK
通讯作者：
Yoder BK
DOI：
10.1073/pnas.0804558105
发表时间：
2008-09-02
影响因子：
11.1
作者：
Breunig, Joshua J.;Sarkisian, Matthew R.;Town, Terrence
通讯作者：
Town, Terrence
影响因子：
9.8
作者：
Cantagrel, Vincent;Silhavy, Jennifer L.;Gleeson, Joseph G.
通讯作者：
Gleeson, Joseph G.