Wolbachia genomes:: revealing the biology of parasitism and mutualism
Wolbachia genomes:: revealing the biology of parasitism and mutualism
复制标题
DOI：
10.1016/j.pt.2005.12.012
复制
发表时间：
2006-02-01
影响因子：
9.6
通讯作者：
Blaxter, M
中科院分区：
文献类型：
--
作者：
Fenn, K;Blaxter, M
沃尔巴克氏体细菌是许多动物物种的内共生伙伴，它们在其中表现为寄生虫（在节肢动物宿主中）或互利主义者（在线虫宿主中）。是什么生物化学和生物学支撑了这些不同的生活方式？最近对感染节肢动物黑腹果蝇和线虫马来丝虫的沃尔巴克氏体基因组进行了完整测序，并对果蝇中发现的三种沃尔巴克氏体菌株进行了部分基因组测序，使这个问题开始得到解决。寄生性节肢动物沃尔巴克氏体的特征在于存在携带锚定重复蛋白的锚定物;这些蛋白可能被输出到宿主细胞以操纵繁殖。在缺乏这些酶的沃尔巴克氏体线虫中，几种生化途径可以将必需的代谢产物递送到线虫宿主。线虫沃尔巴克氏体也可能在调节哺乳动物宿主免疫系统中发挥作用，但测序的沃尔巴克氏体基因组缺乏合成脂多糖的基因，这引发了有关诱导分子性质的问题。沃尔巴克氏体表面蛋白可能具有这种功能。
Wolbachia bacteria are endosymbiotic partners of many animal species, in which they behave as either parasites (in arthropod hosts) or mutualists (in nematode hosts). What biochemistry and biology underpin these diverse lifestyles? The recent complete sequencing of genomes from Wolbachia that infect the arthropod Drosophila melanogaster and the nematode Brugia malayi, together with the partial genome sequencing of three Wolbachia strains found in drosophilids, enables this question to begin to be addressed. Parasitic arthropod Wolbachia are characterized by the presence of phages that carry ankyrin-repeat proteins; these proteins might be exported to the host cell to manipulate reproduction. In nematode Wolbachia, which lack these phages, several biochemical pathways can deliver essential metabolites to the nematode hosts. Nematode Wolbachia might also have a role in modulating the mammalian host immune system but the sequenced Wolbachia genomes lack the genes to synthesize lipopolysaccharide, raising questions about the nature of the inducing molecule. The Wolbachia surface protein might carry out this function.