PROTEOLYTIC ENZYMES OF MAST CELLS

PROTEOLYTIC ENZYMES OF MAST CELLS
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DOI:
10.1111/j.1749-6632.1963.tb53698.x
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发表时间:
1963-01-01
期刊:
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子:
--
通讯作者:
BENDITT, EP
BENDITT, EP
中科院分区:
其他
文献类型:
--
作者:
LAGUNOFF, D;BENDITT, EP

文献摘要

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大鼠的肥大细胞含有一种活性的蛋白水解酶,可以分解酪蛋白、白蛋白和胰岛素。它具有最适的碱性pH,其酯酶活性与胰凝乳酶具有同源性。这种酶(肥大细胞糜酶)与肝素和组胺一起以活性形式存在于肥大细胞特有的大颗粒中。第二种酶(肥大细胞类胰蛋白酶)存在于狗和人的肥大细胞中,与胰腺炎同种。
The mast cells of rat contain an active pro-teolytic enzyme that hydrolyzes casein, albumin and insulin. It has an alkaline pH optimum, and its esterase activity is homospecific with chymotrypsin. The enzyme (mast cell chymase) is present in active form in characteristic large granules of the mast cell along with heparin and histamine. A second enzyme (mast cell tryptase) is present in mast cells of the dog and human which is homospecific with trypsia.