TOXICITY AND DEATHS FROM 3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY)
TOXICITY AND DEATHS FROM 3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY)
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DOI：
10.1016/0140-6736(92)91469-o
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发表时间：
1992-08-15
期刊：
影响因子：
168.9
通讯作者：
DAWLING, S
中科院分区：
文献类型：
--
作者：
HENRY, JA;JEFFREYS, KJ;DAWLING, S
在美国和英国，对3，4-亚甲基二氧基甲基苯丙胺(MDMA)的不良反应的风险现在已经广为人知，但疾病的模式仍然不同。我们报告了我们在1990年至1991年期间的经验。最近，因娱乐场所滥用少量MDMA而导致严重中毒的案例有所增加。在7例死亡中，毒性包括暴发性高热、惊厥、弥散性血管内凝血、横纹肌溶解和急性肾功能衰竭。到目前为止，关于MDMA的这种毒性的报道很少，这可能与药物改变体温调节的潜力和滥用情况有关。此外，我们已经监测了7例肝毒性，并怀疑这种并发症的频率正在增加；出现不明原因黄疸或肝肿大的年轻人应该寻找滥用MDMA的病史。我们还描述了在道路交通事故中发现MDMA的5名受试者。滥用MDMA可能会产生严重的急性毒性影响；关于长期发病率的数据很少，这值得未来密切监测。
The risk of adverse reactions to 3,4-methylenedioxymethamphetamine (MDMA), more commonly known as ''ecstasy'', is now widely known in both the USA and UK, but the patterns of illness remain varied. We report our experience during 1990 and 1991.There has been a recent increase in cases of severe toxicity following recreational misuse of small amounts of MDMA. Among 7 fatalities, the pattern of toxicity included fulminant hyperthermia, convulsions, disseminated intravascular coagulation, rhabdomyolysis, and acute renal failure. Until now, there have been few reports of this type of toxicity from MDMA, which may be related both to the potential of the drug to alter thermoregulation and to the circumstances of misuse. In addition, we have monitored 7 cases of hepatotoxicity and suspect that the frequency of this complication is increasing; a history of MDMA misuse should be sought in young people presenting with unexplained jaundice or hepatomegaly. We also describe 5 subjects involved in road traffic accidents in whom MDMA was identified.Misuse of MDMA can have severe acute toxic effects; few data are available concerning long-term morbidity, and this deserves close monitoring in future.