Myonectin Predicts the Development of Type 2 Diabetes
Myonectin Predicts the Development of Type 2 Diabetes
复制标题
肌连蛋白预测 2 型糖尿病的发展
DOI：
10.1210/jc.2017-01604
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发表时间：
2018-01-01
影响因子：
5.8
通讯作者：
Yang, Gangyi
中科院分区：
文献类型：
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作者：
Li, Kejia;Liao, Xin;Yang, Gangyi
背景：肌连接素已被确定为一种肌因子，主要在骨骼肌中表达。然而，其临床意义在很大程度上是未知的。目的：本研究旨在通过横断面和介入研究探讨肌连接素（C1q肿瘤坏死因子-a相关蛋白亚型15）与2型糖尿病（T2DM）的关系。设计：在另一项单独的研究中，通过口服葡萄糖耐量试验、45分钟的运动、脂质输注和正糖-高胰岛素钳夹（EHCs）来研究肌连接素与胰岛素抵抗（HOMA-IR）和T2DM稳态模型评估的关系。采用酶联免疫吸附法测定循环肌粘连蛋白。患者：本研究招募了104名新诊断的T2DM (nT2DM)， 109名糖耐量受损（IGT）和128名健康个体。结果：nT2DM和IGT组循环肌粘连素浓度高于正常组（82.3 +/- 47.6和68.9 +/- 46.6 vs. 45.2 +/- 23.5 mu g/L, P < 0.05或P < 0.01）。研究还发现，在nT2DM个体中，循环肌连接素高于IGT受试者。血浆肌粘连素与腰臀比、体脂百分比、甘油三酯、空腹血糖、葡萄糖超载后2小时血糖、空腹胰岛素、血红蛋白A1c和HOMA-IR呈正相关，与所有研究人群的胰岛素敏感性指数呈负相关。多因素logistic回归分析显示，循环肌粘连素水平与IGT和T2DM显著相关。在健康的年轻人中，45分钟的运动并没有改变循环肌连接素的水平。循环肌粘连素水平在口服葡萄糖挑战或EHC的反应中没有显著改变。此外，脂质输注引起的急性游离脂肪酸水平升高对循环肌粘连蛋白无影响。结论：这些数据提示肌连接素可能是预测糖尿病前期和糖尿病发展的有用标志物。
Context: Myonectin has been identified as a myokine, expressed predominantly in skeletal muscle. However, its clinical implications are largely unknown.Objective: The aim of this study is to investigate the relationship between myonectin (C1q tumor necrosis factor-a-related protein isoform 15) and type 2 diabetes mellitus (T2DM) in cross-sectional and interventional studies.Design: In a separate study, oral glucose tolerance tests, a 45-minute bout of exercise, lipid infusions, and euglycemic-hyperinsulinemic clamps (EHCs) were performed to investigate the association of myonectin with homeostasis model assessment of insulin resistance (HOMA-IR) and T2DM. Circulating myonectin was measured by enzyme-linked immunosorbent assay.Patients: One hundred four newly diagnosed T2DM (nT2DM), 109 impaired glucose tolerance (IGT), and 128 healthy individuals were recruited for this study.Results: nT2DM and IGT subjects had higher circulating myonectin concentrations than normal subjects (82.3 +/- 47.6 and 68.9 +/- 46.6 vs. 45.2 +/- 23.5 mu g/L, P < 0.05 or P < 0.01). It was also found that in nT2DM individuals, circulating myonectin was higher than in IGT subjects. Plasma myonectin correlated positively with waist/hip ratio, percentageof body fat, triglyceride, fasting blood glucose, 2-hour blood glucose after glucose overload, fasting insulin, hemoglobin A1c, and HOMA-IR and negatively with the insulin sensitivity index in all of the study population. Multivariate logistic regression analysis revealed that circulating myonectin levels were significantly correlated with IGT and T2DM. A 45-minute bout of exercise did not change circulating myonectin levels in healthy, young individuals. Circulating myonectin levels were not significantly altered in response to an oral glucose challenge or EHC. In addition, acute elevated free fatty acid levels induced by lipid infusion had no effects on circulating myonectin.Conclusions: These data suggest that myonectin may be a useful marker in predicting the development of prediabetes and diabetes.