Leptin and its role in hippocampal synaptic plasticity.
Leptin and its role in hippocampal synaptic plasticity.
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DOI：
10.1016/j.plipres.2006.03.001
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发表时间：
2006-09
影响因子：
13.6
通讯作者：
Irving, Andrew
中科院分区：
文献类型：
--
作者：
Harvey, Jenni;Solovyova, Natasha;Irving, Andrew
有充分的证据表明，瘦素激素通过下丘脑的作用在调节食物摄入和体重方面起着关键作用。然而，瘦素受体在整个大脑中表达，在海马体中发现了高水平。越来越多的证据表明，瘦素对中枢神经系统的功能有广泛的作用，特别是在学习和记忆方面。最近的研究表明，瘦素缺乏或不敏感的啮齿动物在莫里斯水迷宫中进行的海马突触可塑性和空间记忆任务中受到损害。此外，直接将瘦素注入大脑有助于海马长期增强（LTP），并改善小鼠的记忆表现。也有证据表明，在细胞水平上，瘦素具有通过增强NMDA受体功能将海马短期增强（STP）转化为LTP的能力。最近的数据表明，瘦素还可以诱导一种新型的NMDA受体依赖性海马长期抑郁。在此，我们回顾了瘦素在调节海马突触可塑性中发挥关键作用的证据，并讨论了脂质信号级联在这一过程中的作用。
It is well documented that the hormone leptin plays a pivotal role in regulating food intake and body weight via its hypothalamic actions. However, leptin receptors are expressed throughout the brain with high levels found in the hippocampus. Evidence is accumulating that leptin has widespread actions on CNS function and in particular learning and memory. Recent studies have demonstrated that leptin-deficient or -insensitive rodents have impairments in hippocampal synaptic plasticity and in spatial memory tasks performed in the Morris water maze. Moreover, direct administration of leptin into the brain facilitates hippocampal long-term potentiation (LTP), and improves memory performance in mice. There is also evidence that at the cellular level leptin has the capacity to convert hippocampal short term potentiation (STP) into LTP, via enhancing NMDA receptor function. Recent data indicates that leptin can also induce a novel form of NMDA receptor-dependent hippocampal long-term depression. Here, we review the evidence implicating a key role for the hormone leptin in modulating hippocampal synaptic plasticity and discuss the role of lipid signaling cascades in this process.
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影响因子：
4.7
作者：
Durakoglugil M;Irving AJ;Harvey J
通讯作者：
Harvey J
影响因子：
5.3
作者：
Cathala, L;Misra, C;Cull-Candy, S
通讯作者：
Cull-Candy, S
影响因子：
4.8
作者：
Bjorbaek, C;Uotani, S;Flier, JS
通讯作者：
Flier, JS
DOI：
10.1073/pnas.95.2.741
发表时间：
1998-01-20
影响因子：
11.1
作者：
Elmquist, JK;Ahima, RS;Saper, CB
通讯作者：
Saper, CB
DOI：
10.1152/ajpendo.2000.278.6.e1158
发表时间：
2000-06-01
影响因子：
5.1
作者：
Banks, WA;Clever, CM;Farrell, CL
通讯作者：
Farrell, CL