Targeting male mosquito swarms to control malaria vector density
Targeting male mosquito swarms to control malaria vector density
复制标题
DOI：
10.1371/journal.pone.0173273
复制
发表时间：
2017-03-09
期刊：
影响因子：
3.7
通讯作者：
Diabate, Abdoulaye
中科院分区：
文献类型：
--
作者：
Sawadogo, Simon Peguedwinde;Niang, Abdoulaye;Diabate, Abdoulaye
疟疾控制程序因蚊子媒介种群中杀虫剂的耐药性传播而受到危害。据估计，抵抗的传播每年可能导致120000人死亡，并干扰持续控制的前景或消除疟疾的可行性。抗药性管理策略发展的另一个并发症是，除了杀虫剂抗性外，蚊子行为以减少LLIN和IRS影响的方式演变。蚊子可以通过优先喂食和休息在人类房屋外和/或在人们入睡前的晚上活跃来避免Llin和IRS控制。我们对蚊子群的了解的最新发展表明，针对蚊子群的新工具可以降低疟疾载体的高生殖速率。靶向大量疟疾媒介可能会提供一种有效的控制方法来抵消蚊子产生的行为抵抗。在这里，我们评估了Anopheles gambiae S.L.系统喷雾的系统喷涂的影响。使用混合氨基甲酸酯和拟除虫菊酯气溶胶。测量了这种干预对载体密度，女性授精率和男性年龄结构的影响。我们表明，与对照人群相比，人口大小的群体和一些寻求伴侣的女性的群体杀戮和一些寻求伴侣的女性的大量杀害导致了80％的降低。观察到女性授精率的显着降低和男性年龄结构的显着转移向年轻男性无法交配。因此，这项范式迁移研究表明，主要针对雄性而不是女性的靶向可能会对蚊子人群产生巨大影响。
Malaria control programs are being jeopardized by the spread of insecticide resistance in mosquito vector populations. It has been estimated that the spread of resistance could lead to an additional 120000 deaths per year, and interfere with the prospects for sustained control or the feasibility of achieving malaria elimination. Another complication for the development of resistance management strategies is that, in addition to insecticide resistance, mosquito behavior evolves in a manner that diminishes the impact of LLINs and IRS. Mosquitoes may circumvent LLIN and IRS control through preferential feeding and resting outside human houses and/or being active earlier in the evening before people go to sleep. Recent developments in our understanding of mosquito swarming suggest that new tools targeting mosquito swarms can be designed to cut down the high reproductive rate of malaria vectors. Targeting swarms of major malaria vectors may provide an effective control method to counteract behavioral resistance developed by mosquitoes. Here, we evaluated the impact of systematic spraying of swarms of Anopheles gambiae s.l. using a mixed carbamate and pyrethroid aerosol. The impact of this intervention on vector density, female insemination rates and the age structure of males was measured. We showed that the resulting mass killing of swarming males and some mate-seeking females resulted in a dramatic 80% decrease in population size compared to a control population. A significant decrease in female insemination rate and a significant shift in the age structure of the male population towards younger males incapable of mating were observed. This paradigm-shift study therefore demonstrates that targeting primarily males rather than females, can have a drastic impact on mosquito population.