Testosterone and the control of gonadotropin secretion in the male rhesus monkey (Macaca mulatta).
Testosterone and the control of gonadotropin secretion in the male rhesus monkey (Macaca mulatta).
复制标题
雄性恒河猴（Macaca mulatta）的睾酮和促性腺激素分泌的控制。
作者：
T. Plant;D. L. Hess;J. Hotchkiss;Ernst Knobil
对成年雄性恒河猴双侧去势前的血浆睾酮(T)和雌二醇(E)水平进行了测定。从切除当天开始，皮下注射含T硅胶胶囊和皮下注射T油，定量复制去势前血浆T浓度的昼夜变化规律。皮下植入含E的硅橡胶胶囊，复制术前血浆E水平。用睾酮和卵泡刺激素替代治疗可将血清中的促黄体生成素和促卵泡刺激素浓度维持在或低于术前控制范围。单独用T替代也可以将循环中的促性腺激素维持在与去势前观察到的浓度相似的水平。停止T替代治疗，同时将血浆E维持在去势前的水平，导致循环中的促黄体生成素和卵泡刺激素浓度上升到接近于停止所有类固醇治疗时观察到的浓度。这些发现不能提供证据支持“抑制素”假说，并暗示了抑制素的作用机制。
Plasma levels of testosterone (T) and estradiol (E) were determined in intact adult male rhesus monkeys before bilateral castration. Beginning on the day of orchidectomy, the precastration diurnal patterns in plasma T concentrations were replicated quantitatively by the sc implantation of T-containing Silastic capsules and by sc injections of T in oil. Preoperative plasma E levels were replicated by the sc implantation of E-containing Silastic capsules. Replacement with T and E maintained serum LH and FSH concentrations within or below the preoperative control ranges. Replacement with T alone also maintained circulating gonadotropins at concentrations similar to those observed before castration. Withdrawal of T replacement, while maintaining plasma E at precastration levels, resulted in a rise in circulating LH and FSH to concentrations approximating those observed when all steroid treatment was discontinued. These findings fail to provide evidence in support of the “inhibin” hypothesis and suggest that t...