The Trouble with CBD Oil.
The Trouble with CBD Oil.
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DOI：
10.1159/000489287
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发表时间：
2018-06-01
影响因子：
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通讯作者：
Hazekamp, Arno
中科院分区：
文献类型：
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作者：
Hazekamp, Arno
在短短几年内，大麻二酚（CBD）在世界各地变得非常受欢迎。CBD最初被发现是一种有效的儿童Dravet综合征的自我药物，现在被出售并用于治疗各种医疗条件和生活方式疾病。大麻素CBD是更臭名昭著的四氢大麻酚（THC）的一种非精神活性异构体，有越来越多的给药模式，但最常见的是CBD油。目前，市场上活跃着数十家（如果不是数百家的话）CBD油的生产商和销售商，而且他们的数量还在迅速增加。涉及的人从为家人和（Facebook）朋友准备小规模油的个人到合成药房，制药公司和持牌大麻生产商。尽管CBD的可用性越来越高，但这种新的“奇迹疗法”的合法性、质量和安全性仍存在许多不确定性。因此，从国家卫生组织和农业游说者到世界卫生组织和食品和药物管理局，CBD受到了许多层面的审查。核心问题是CBD是否只是一种食品补充剂，一种正在研究的新药，甚至是一种麻醉剂。本文概述了与CBD产品成分相关的已知风险和问题，并根据准确的标签和更科学支持的健康声明提出了更好的监管控制建议。本文的目的是为了更好地了解CBD产品目前生产、使用和广告方式的利弊。
In just a few years, cannabidiol (CBD) has become immensely popular around the world. After initially being discovered as an effective self-medication for Dravet syndrome in children, CBD is now sold and used to treat a wide range of medical conditions and lifestyle diseases. The cannabinoid CBD, a non-psychoactive isomer of the more infamous tetrahydrocannabinol (THC), is available in a growing number of administration modes, but the most commonly known is CBD oil. There are currently dozens, if not hundreds, of producers and sellers of CBD oils active in the market, and their number is increasing rapidly. Those involved vary from individuals who prepare oils on a small scale for family and (Facebook) friends to compounding pharmacies, pharmaceutical companies, and licensed cannabis producers. Despite the growing availability of CBD, many uncertainties remain about the legality, quality, and safety of this new "miracle cure." As a result, CBD is under scrutiny on many levels, ranging from national health organizations and agricultural lobbyists to the WHO and FDA. The central question is whether CBD is simply a food supplement, an investigational new medicine, or even a narcotic. This overview paper looks into the known risks and issues related to the composition of CBD products, and makes recommendations for better regulatory control based on accurate labeling and more scientifically supported health claims. The intention of this paper is to create a better understanding of the benefits versus the risks of the current way CBD products are produced, used, and advertised.