Salivary mucins in host defense and disease prevention.
Salivary mucins in host defense and disease prevention.
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预防宿主防御和疾病的唾液粘蛋白。
DOI：
10.3402/jom.v7.29759
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发表时间：
2015
影响因子：
4.5
通讯作者：
Ribbeck K
中科院分区：
文献类型：
--
作者：
Frenkel ES;Ribbeck K
粘液在整个身体的潮湿上皮表面上形成保护涂层，容纳微生物群，并在宿主防御中发挥关键作用。粘蛋白是粘液的主要结构成分，它产生粘弹特性，是凝胶层的关键成分，可以防止病原体入侵。改变的粘蛋白产生与溃疡性结肠炎、哮喘和囊性纤维化等疾病有关，这突出了粘蛋白在维持体内平衡中的重要性。不同类型的粘蛋白存在于整个身体的不同位置，如胃肠道，肺和女性生殖道，但这次审查将集中在口腔中的粘蛋白。唾液粘蛋白的结构，口腔内的定位和防御机制将被讨论。这些概念，然后将被应用到目前已知的口腔疾病，如艾滋病毒/艾滋病，口腔念珠菌病，龋齿的粘蛋白的保护功能。
Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical components of the gel layer that protect against invading pathogens. Altered mucin production has been implicated in diseases such as ulcerative colitis, asthma, and cystic fibrosis, which highlights the importance of mucins in maintaining homeostasis. Different types of mucins exist throughout the body in various locations such as the gastrointestinal tract, lungs, and female genital tract, but this review will focus on mucins in the oral cavity. Salivary mucin structure, localization within the oral cavity, and defense mechanisms will be discussed. These concepts will then be applied to present what is known about the protective function of mucins in oral diseases such as HIV/AIDS, oral candidiasis, and dental caries.