Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin
Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin
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DOI：
10.1016/j.bmcl.2005.01.064
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发表时间：
2005-03-15
影响因子：
2.7
通讯作者：
Nicolau, C
中科院分区：
文献类型：
--
作者：
Fylaktakidou, KC;Lehn, JM;Nicolau, C
合成了九种肌醇三焦磷酸盐。它们作为血红蛋白（Hb）的变构效应物的能力已在体外用游离Hb和全血测量。所有合成的化合物都与游离Hb结合，并且在一定程度上也能够穿过全血样品中红细胞（RBC）的质膜，降低Hb对氧的亲和力。氧-血红蛋白解离曲线显着转向较高的氧分压值，无论是游离血红蛋白和细胞内血红蛋白在全血中。(c)2005爱思唯尔有限公司保留所有权利。
Nine inositol tripyrophosphate (ITPP) salts have been synthesized. Their ability to act as allosteric effectors of haemoglobin (Hb) has been measured in vitro with free Hb and whole blood. All the synthesized compounds bound to free Hb and were also able to cross, to a certain extent, the plasma membrane of the red blood cells (RBCs) in whole blood samples, lowering the affinity of Hb for oxygen. The oxy-haemoglobin dissociation curves were significantly shifted towards higher values of oxygen partial pressures, both for free Hb and for intracellular Hb in whole blood. (c) 2005 Elsevier Ltd. All rights reserved.