Squamous cell carcinoma-related antigen in children with acute asthma
Squamous cell carcinoma-related antigen in children with acute asthma
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DOI：
10.1016/s1081-1206(10)60993-3
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发表时间：
2005-03-01
影响因子：
5.9
通讯作者：
Hamasaki, Y
中科院分区：
文献类型：
--
作者：
Nishi, N;Miyazaki, M;Hamasaki, Y
背景资料：在过敏性疾病（如特应性皮炎和支气管哮喘）患者中观察到鳞状细胞癌相关抗原（SCCA）的血清水平升高。T（H）2细胞因子参与过敏性疾病的发病机制，刺激培养的人气道上皮细胞合成新的SCCA目的：探讨儿童哮喘急性发作时SCCA水平是否升高，以及TH 2细胞因子白细胞介素4（IL-4）和IL-13是否与SCCA水平相关。采用酶免疫法测定哮喘急性发作期血清SCCA、IL-4和IL-13水平（入院时）和恢复期（症状消退后）。结果：在参与这项研究的35名儿童中，急性期血清SCCA水平显著升高（平均SD 3.09 +/- 2.03 ng/mL）与哮喘急性发作的恢复期（平均+/- SD，1.47 +/- 0.64 ng/mL）相比（P < .001）。在12名儿童中，IL-13水平被观察到与SCCA水平在恢复期（r = 0.68，P = 0.02），但不是在急性期的哮喘急性加重。结论：血清SCCA水平增加在急性期的哮喘急性加重。在此阶段，SCCA的合成增加与IL-13无关，而是由其他未定义的刺激介导。IL-13可能有助于哮喘儿童SCCA的基础产生。
Background: Increased serum levels of squamous cell carcinoma-related antigen (SCCA) have been observed in patients with allergic disorders, such as atopic dermatitis and bronchial asthma. T(H)2 cytokines, which are known to be involved in the pathogenesis of allergic disorders stimulate new synthesis of SCCA in cultured human airway epithelial cells.Objective: To investigate whether SCCA levels increase during acute exacerbations of asthma in children and whether the TH2 cytokines, interleukin 4 (IL-4) and IL-13, are associated with SCCA levels.Methods: Serum levels of SCCA, IL-4, and IL-13 were measured by enzyme immunoassay during the acute phase of an asthma exacerbation (on hospital admission) and in the recovery phase (after symptoms had subsided).Results: In the 35 children who participated in this study, serum levels of SCCA were significantly elevated in the acute phase (mean SD 3.09 +/- 2.03 ng/mL) compared with the recovery phase (mean +/- SD, 1.47 +/- 0.64 ng/mL) of an asthma exacerbation (P < .001). In 12 children, the IL-13 levels were observed to correlate with SCCA levels during the recovery phase (r = 0.68, P = .02) but not during the acute phase of an asthma exacerbation.Conclusions: Serum SCCA levels increase during the acute phase of an asthma exacerbation. During this phase, the increased synthesis of SCCA is not associated with IL-13 but rather mediated by other undefined stimuli. IL-13 may contribute to the basal production of SCCA in asthmatic children.