Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide?
Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide?
复制标题
性早熟与下丘脑精氨酸-苯丙氨酸-酰胺相关肽的表达有关吗？
DOI：
10.22038/ijbms.2017.9397
复制
发表时间：
2017-10
影响因子：
2.2
通讯作者：
Yu J
中科院分区：
文献类型：
--
作者：
He Y;Sun W;Yu J
促性腺激素释放激素（GnRH）在中枢性性早熟中的上调和下调尚不清楚。近年来，神经内分泌学研究表明，精氨酸-苯丙氨酸RF-酰胺相关肽（RFRPs）在不同的生殖现象如发情周期和妊娠中对GnRH分泌起调控作用，但RFRPs在青春期及其相关病理状态--性早熟中的确切作用尚不清楚。本文推测RFRP是一种青春期调节肽，可能具有预防性早熟的作用。根据以往对青春期激素波动的研究，RFRP可能具有控制GnRH过早分泌，避免中枢性性早熟的作用。
The up-regulation and down-regulation of gonadotropin-releasing hormone (GnRH) in central precocious puberty is not yet known. However, recent advances in neuroendocrinology have shown the controlling role of arginine-phenylalanine RF-amide-related peptides (RFRPs) on GnRH secretion in different phenomenon of reproduction such as estrus cycle and pregnancy, but the exact role of RFRPs in puberty and its related pathologic condition, precocious puberty, is not clear yet. This paper hypothesizes that RFRP is a regulatory peptide of puberty and might prevent the precocious puberty. On the basis of previous studies on hormonal fluctuations at the time of puberty, RFRP might have a role on controlling of premature secretion of GnRH and avoiding central precocious puberty.