METABOLIC BASIS OF OBESITY AND NONINSULIN-DEPENDENT DIABETES-MELLITUS
METABOLIC BASIS OF OBESITY AND NONINSULIN-DEPENDENT DIABETES-MELLITUS
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DOI：
10.1002/dmr.5610040803
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发表时间：
1988-12-01
期刊：
影响因子：
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通讯作者：
FERRANNINI, E
中科院分区：
文献类型：
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作者：
GOLAY, A;FELBER, JP;FERRANNINI, E
胰岛素抵抗是单纯性肥胖和非胰岛素依赖型糖尿病（NIDDM）的特征性发现。在这两种综合征中胰岛素抵抗的存在已被各种实验技术所证实，并且已被证明在这两种综合征中都相当明显。特别是，如果在外源性胰岛素输注过程中血糖被钳制在吸收后血糖正常水平，则会导致生理性外周高胰岛素血症（胰岛素钳夹），人们发现全身葡萄糖摄取在对口服葡萄糖具有正常耐受性的肥胖受试者和具有正常身体的NIDDM患者中，前者能够响应口服葡萄糖而维持葡萄糖体内平衡，而后者显然不能这样做。这个简单的事实表明，在全身水平上相同程度的胰岛素抵抗对不同疾病的葡萄糖耐量有非常不同的影响。它进一步表明，除了
Insulin resistance is a characteristic finding in both simple obesity and noninsulin-dependent diabetes (NIDDM).’-’’The presence of insulin resistance in these two syndromes has been documented with the use of a variety of experimental techniques, and has been shown to be rather marked in both. In particular, if plasma glucose is clamped at postabsorptive, euglycemic levels during an exogenous insulin infusion resulting in physiological peripheral hyperinsulinemia (insulin clamp), one finds that whole-body glucose uptake (a measure of the body’s sensitivity ‘to the hormone) is reduced by 40-50% both in obese subjects with normal tolerance to oral glucose and in NIDDM patients with normal body Nevertheless, the former are capable of maintaining glucose homeostasis in response to oral glucose while the latter obviously fail to do so. This simple fact indicates that the same degree of insulin resistance at the whole-body level can have a very different impact on glucose tolerance in different diseases. It further suggests that factors other than