An evaluation of cyclooxygenase-2 as a prognostic biomarker in mid-gut carcinoid tumours
An evaluation of cyclooxygenase-2 as a prognostic biomarker in mid-gut carcinoid tumours
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DOI：
10.1159/000107555
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发表时间：
2007-01-01
影响因子：
4.1
通讯作者：
McGinty, Ann
中科院分区：
文献类型：
--
作者：
Cadden, Ian;Johnston, Brian T.;McGinty, Ann
背景/目的：中肠类癌（Mid- gut carcinoids， MGC）是最常见的胃肠道类癌。MGC缺乏可靠的预后指标。Cox- 2和Bcl- 2作为预后生物标志物在一组特征明确的非阑尾MGC中被评估。方法：对37例原发性MGC肿瘤组织进行Cox- 2和Bcl- 2的免疫组化检测。9例还检查了继发性病变的组织。该研究评估了肿瘤相关的Cox- 2和Bcl- 2表达是否与患者生存有关。结果：30/ 36例原发性肿瘤中有Cox- 2表达。当对所有肿瘤进行分析时，Cox回归分析显示，随着Cox- 2组织评分(强度！比例;风险比1.53,95% CI 0.93, 2.52；P = 0.09)。对Cox- 2阳性肿瘤的分析显示，组织评分升高与生存率降低之间存在高度显著的关联（风险比3.03,95% CI 1.33, 6.91; p = 0.008）。肿瘤相关Bcl- 2表达对患者生存无影响（风险比1.12,95% CI 0.42, 2.99; p = 0.82）。Cox- 2与Bcl- 2表达无显著相关性（x(2) p = 0.16）， Cox- 2组织评分与Bcl- 2表达无显著相关性（MWU p = 0.59）。原发肿瘤及其相应继发病变的Cox- 2组织评分分析显示，后者的组织评分有统计学意义的升高趋势（Wilcoxon p = 0.04）。结论：本研究提供了Cox- 2在原发性MGC中的表达可能与更负面的预后前景相关的证据。版权所有(C) 2007 S. Karger AG，巴塞尔
Background/ Aims: Mid- gut carcinoids (MGC) are the most common of the gastrointestinal carcinoid tumours. There is a lack of reliable prognostic indicators for MGC. Cox- 2 and Bcl- 2 were evaluated as prognostic biomarkers in a cohort of well- characterised non- appendiceal MGC. Methods: Tissue from the primary MGC tumours of 37 patients was subjected to immunohistochemical detection of Cox- 2 and Bcl- 2. In 9 cases, tissue from secondary lesions was also examined. The study assessed whether tumour- associated Cox- 2 and Bcl- 2 expression were related to patient survival. Results: Cox- 2 expression was demonstrated in 30/ 36 primary tumours. When all tumours were analysed, Cox regression analysis indicated a trend towards worsening survival with increasing Cox- 2 histoscore (intensity ! proportion; hazard ratio 1.53, 95% CI 0.93, 2.52; p = 0.09). Analysis of Cox- 2- positive tumours revealed a highly significant association between increasing histoscore and decreased survival (hazard ratio 3.03, 95% CI 1.33, 6.91; p = 0.008). Tumour- associated Bcl- 2 expression had no effect on patient survival (hazard ratio 1.12, 95% CI 0.42, 2.99; p = 0.82). There was no significant association between Cox- 2 and Bcl- 2 expression (x(2) p = 0.16), or Cox- 2 histoscore and Bcl- 2 expression (MWU p = 0.59). Analysis of the Cox- 2 histoscores of primary tumours and their corresponding secondary lesions revealed a statistically significant trend towards increasing histoscore in the latter (Wilcoxon p = 0.04). Conclusions: This study has provided evidence that Cox- 2 expression in primary MGC may be associated with a more negative prognostic outlook. Copyright (C) 2007 S. Karger AG, Basel.