MRNA and cytoskeletal filaments

MRNA and cytoskeletal filaments
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DOI:
10.1016/s0955-0674(97)80159-7
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发表时间:
1997-02-01
影响因子:
7.5
通讯作者:
Singer, RH
Singer, RH
中科院分区:
生物学2区
文献类型:
--
作者:
Bassell, G;Singer, RH

文献摘要

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一些 mRNA 定位到不同的细胞内区域是通过 mRNA 与细胞骨架丝的相互作用来实现的。 RNA-细胞骨架相互作用的存在会影响 mRNA 的运输、锚定和翻译。最近对活细胞中 RNA 运动的分析表明 RNA 颗粒的形成及其沿着微管的主动运输。 mRNA 的锚定和翻译可能是通过 F-肌动蛋白和延伸因子 1 α 正交网络的相互作用介导的。
The localization of some mRNAs to distinct intracellular regions is achieved through interactions of the mRNA with cytoskeletal filaments. RNA-cytoskeletal interactions exist that influence the transport, anchoring and translation of mRNA. Recent analysis of RNA movements in living cells suggests the formation of RNA granules and their active transport along microtubules. The anchoring and translation of mRNA may be mediated by interactions with orthogonal networks of F-actin and elongation factor 1 alpha.