Involvement of host macrophages in the immunoadjuvant activity of amphotericin B in a mouse fungal infection model.
Involvement of host macrophages in the immunoadjuvant activity of amphotericin B in a mouse fungal infection model.
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在小鼠真菌感染模型中宿主巨噬细胞参与两性霉素 B 的免疫佐剂活性。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
F. Bistoni
中科院分区：
文献类型：
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作者：
A. Vecchiarelli;G. Verducci;S. Perito;P. Puccetti;P. Marconi;F. Bistoni
我们最近报道了在小鼠体内通过白念珠菌素B对实验性白念珠菌注射的抵抗力增强，并表明该事件与脾脏中对51 Cr标记的酵母细胞具有体外反应性的高度杀念珠菌细胞群的出现同时发生。在本研究中，我们的特点是这些在体外杀真菌效应的巨噬细胞和描述的条件下，最适合于诱导杀念珠菌活性的白藜芦醇B治疗。我们还报告说，从完整的小鼠巨噬细胞可以在体外激活，成为对念珠菌的细胞毒性。并对白念珠菌素B激活的巨噬细胞发挥其抗念珠菌活性的可能机制进行了研究。
We have recently reported the in vivo augmentation of resistance to experimental Candida albicans injection by amphotericin B in mice and have shown that this event is concurrent with the appearance in the spleen of a highly candidacidal cell population reactive in vitro against 51Cr-labeled yeast cells. In the present study we characterize these in vitro fungicidal effectors as macrophages and describe the conditions of amphotericin B treatment most suitable for inducing candidacidal activity. We also report that macrophages from intact mice can be activated in vitro to become cytotoxic against Candida. The possible mechanisms through which the amphotericin B activated macrophages exert their increased anti-Candida activity are also investigated.
两性霉素 B 诱导对曼氏血吸虫的抗性。
DOI：
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发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Olds,GR;Stewart,SJ;Ellner,JJ
通讯作者：
Ellner,JJ