IgMk paraprotein from gammopathy patient can bind to cardiolipin and interfere with coagulation assay: a case report.
IgMk paraprotein from gammopathy patient can bind to cardiolipin and interfere with coagulation assay: a case report.
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丙种球蛋白病患者的 IgMk 副蛋白可与心磷脂结合并干扰凝血测定：病例报告
DOI：
10.1186/s12865-017-0213-0
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发表时间：
2017-06-23
期刊：
影响因子：
3
通讯作者：
Yang CD
中科院分区：
文献类型：
--
作者：
Wu XY;Yin YF;Teng JL;Zhang LW;Yang CD
背景单克隆丙种球蛋白病是一组以分泌单克隆免疫球蛋白（M蛋白或副蛋白）为特征的浆细胞增殖性疾病。一些罕见的病例显示副蛋白作为自身抗体的特异性亲和力。我们报告一位单克隆丙种球蛋白病（MGUS）患者，伴随抗心磷脂抗体（aCL）的显著升高和凝血因子活性的广泛降低，然而，无任何抗磷脂综合征（APS）的临床体征结果进一步研究表明，该患者IgM κ副蛋白具有抗磷脂抗体活性，可与心磷脂结合，结论本例患者凝血试验异常，受IgM κ副蛋白干扰，不能预测出血风险。
BackgroundThe monoclonal gammopathies are a group of plasma-cell proliferative disorders characterized by the secretion of monoclonal immunoglobulin (M protein or paraprotein). Some rare cases have revealed the specific affinity of paraprotein as autoantibody. Here we report a patient with monoclonal gammopathy of undetermined significance (MGUS) accompanied by a remarkable increase of anticardiolipin antibody (aCL) and an extensively decreased coagulation factor activity, however, without any clinical signs of antiphospholipid syndrome (APS) and bleeding.ResultsOur further investigation indicated that IgMκ paraprotein of this patient possessed an antibody activity against phospholipids so as to bind to cardiolipin and interfere with coagulation assay in vitro.ConclusionsThis case might be indicative that an abnormality of coagulation tests, disturbed by IgMκ paraprotein, does not predict a risk of bleeding in this patient.