c-Met expression and activity in urogenital cancers - novel aspects of signal transduction and medical implications.
c-Met expression and activity in urogenital cancers - novel aspects of signal transduction and medical implications.
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DOI：
10.1186/s12964-017-0165-2
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发表时间：
2017-02-17
期刊：
影响因子：
--
通讯作者：
Friedrich K
中科院分区：
文献类型：
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作者：
Hass R;Jennek S;Yang Y;Friedrich K
C-Met是一种受体酪氨酸激酶，在胚胎发育、器官发生和伤口愈合过程中具有多种功能，并在各种上皮细胞中表达。c-Met的配体是肝细胞生长因子（HGF），其尤其由间充质基质/干（MSC）细胞分泌。c-Met的生理功能主要集中在细胞运动和侵入性生长的过程中。在许多癌症中观察到异常的c-Met表达和活性，并对细胞恶性肿瘤做出主要贡献。重要的是，HGF/c-Met信号传导在癌细胞和肿瘤间质之间的通信中至关重要。在这里，我们回顾了最近的研究结果的作用失调c-Met在泌尿生殖系统肿瘤，如膀胱癌，前列腺癌和卵巢癌。我们把重点放在新的方面，癌症相关的c-Met表达调控的HGF依赖和HGF独立的非经典机制。此外，这篇评论的重点是c-Met触发的信号与泌尿生殖系统肿瘤发生的潜在相关性，并对策略，以具体抑制c-Met的活性。
C-Met is a receptor tyrosine kinase with multiple functions throughout embryonic development, organogenesis and wound healing and is expressed in various epithelia. The ligand of c-Met is Hepatocyte Growth Factor (HGF) which is secreted among others by mesenchymal stroma/stem (MSC) cells. Physiological c-Met functions are centred around processes that underly cellular motility and invasive growth. Aberrant c-Met expression and activity is observed in numerous cancers and makes major contributions to cell malignancy. Importantly, HGF/c-Met signaling is crucial in the context of communication between cancer cells and the the tumor stroma. Here, we review recent findings on roles of dysregulated c-Met in urogenital tumors such as cancers of the urinary bladder, prostate, and ovary. We put emphasis on novel aspects of cancer-associated c-Met expression regulation on both, HGF-dependent and HGF-independent non-canonical mechanisms. Moreover, this review focusses on c-Met-triggered signalling with potential relevance for urogenital oncogenesis, and on strategies to specifically inhibit c-Met activity.