PHARMACOLOGICAL EVIDENCE FOR THE INVOLVEMENT OF SEROTONERGIC MECHANISMS IN DIFFUSE NOXIOUS INHIBITORY CONTROLS (DNIC)
PHARMACOLOGICAL EVIDENCE FOR THE INVOLVEMENT OF SEROTONERGIC MECHANISMS IN DIFFUSE NOXIOUS INHIBITORY CONTROLS (DNIC)
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DOI：
10.1016/0006-8993(82)90718-1
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
LEBARS, D
中科院分区：
文献类型：
--
作者：
CHITOUR, D;DICKENSON, AH;LEBARS, D
在麻醉大鼠上研究了多巴胺能神经元参与作用于脊髓背角会聚神经元的弥漫性伤害性抑制控制（DNIC）的机制。记录了通过经皮电刺激后爪感受野激活的神经元（35个），这些神经元产生清晰的大A纤维和C纤维反应。这些活动的条件DNIC，诱发的伤害性热应用于尾巴或鼻子的伤害性捏。Cinanserin（4 mg/kg i.v.）和甲麦角林（5 mg/kg i. v.），5-羟色胺（5-HT）受体阻断剂，强烈降低DNIC的抑制作用，而对非条件反应没有显着影响。5-羟色胺酸（5-HT合成的抑制剂）可显著增强DNIC的作用。结果表明，在DNIC的下行多巴胺能通路的重要作用。该系统的功能作用进行了讨论。
The involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC) acting on dorsal horn convergent neurons was studied in the anesthetized rat. Neurons (35) activated by transcutaneous electrical stimulation of their hindpaw receptive fields giving clear large A-fiber and C-fiber responses were recorded. These activities were conditioned by DNIC, evoked by either noxious heat applied to the tail or noxious pinch of the nose. Cinanserin (4 mg/kg i.v.) and metergoline (5 mg/kg i.v.), serotonin (5-HT) receptor blockers, strongly reduced the inhibitory effects of DNIC while having no significant effect on the non-conditioned responses. 5-Hydroxytryptophan, a precursur for 5-HT synthesis, significantly potentiated the effect of DNIC. The results indicate an important role for descending serotonergic pathways in DNIC. The functional role of this system is discussed.