PES1 is regulated by CD44 in liver cancer stem cells via miR-105-5p
PES1 is regulated by CD44 in liver cancer stem cells via miR-105-5p
复制标题
肝癌干细胞中PES1通过miR-105-5p受CD44调控
DOI：
10.1002/1873-3468.13459
复制
发表时间：
2019-07-01
期刊：
影响因子：
3.5
通讯作者：
Shen, Li
中科院分区：
文献类型：
--
作者：
Wei, Shiruo;Liu, Kaiyu;Shen, Li
Pescadillo (PES1) is a key molecule for ribosome formation in mammalian cells. In this study, human hepatoma C3A cells were reprogrammed by four transcription factors, Oct4, Sox2, Klf4 and c-Myc, into induced cancer stem cells, termed C3A-induced cancer stem cells (C3A-iCSCs). We found that PES1 was up-regulated in C3A-iCSCs and promoted cell proliferation. Moreover, the cancer stem cell marker CD44, which is located in the cytomembrane, translocated to the nucleus and was up-regulated in C3A-iCSCs. Our results suggest that CD44 has a negative effect on miR-105-5p. We found that PES1 is a direct target of, and was negatively regulated by, miR-105-5p. In summary, CD44 regulates PES1 in liver cancer stem cells via miR-105-5p to promote cell growth.
