Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step
Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step
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DOI：
10.1128/ec.00351-09
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发表时间：
2010-04-01
期刊：
影响因子：
--
通讯作者：
Akashi, Hiroomi
中科院分区：
文献类型：
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作者：
Sugi, Tatsuki;Kato, Kentaro;Akashi, Hiroomi
弓形虫CDPK1(TgCDPK1)是弓形虫化合物1 nm-PP1的靶标。当TgCDPK1第128位由甘氨酸突变为蛋氨酸时，获得了抗性。1 nm-PP1抑制滑行运动而不抑制微丝分泌，提示TgCDPK1在滑行运动中起作用。
Toxoplasma gondii CDPK1 (TgCDPK1) was found to be the target of the toxoplasmocidal compound 1NM-PP1. When TgCDPK1 was mutated at position 128 from glycine to methionine, resistance was gained. Inhibition of gliding motility without inhibition of micronemal secretion by 1NM-PP1 suggests a function for TgCDPK1 in gliding motility.