Metabolomics
Metabolomics
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DOI：
10.1016/j.cmet.2007.10.005
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发表时间：
2007-11-01
期刊：
影响因子：
29
通讯作者：
Gonzalez, Frank J.
中科院分区：
文献类型：
--
作者：
Idle, Jeffrey R.;Gonzalez, Frank J.
代谢组学是对给定生物体或生物样品中所有代谢物的系统鉴定和定量。核磁共振（NMR）光谱和质谱（MS）提供的高分辨率，沿着强大的化学计量软件，允许同时测定和比较数千种化学实体，这导致了细菌，植物和哺乳动物中小分子生物化学研究的扩展。这些分析平台的持续发展将加速代谢组学的广泛应用，并使小分子进一步整合到系统生物学中。在这里，最近的研究使用代谢组学在异生物质代谢和转基因小鼠突出。
Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and comparison of thousands of chemical entities, which has lead to an expansion of small molecule biochemistry studies in bacteria, plants, and mammals. Continued development of these analytical platforms will accelerate the widespread use of metabolomics and allow further integration of small molecules into systems biology. Here, recent studies using metabolomics in xenobiotic metabolism and genetically modified mice are highlighted.