Longitudinal assessment of resting-state fMRI in temporal lobe epilepsy: A two-year follow-up study
Longitudinal assessment of resting-state fMRI in temporal lobe epilepsy: A two-year follow-up study
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颞叶癫痫静息态 fMRI 的纵向评估：一项为期两年的随访研究
DOI：
10.1016/j.yebeh.2019.106858
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发表时间：
2019
影响因子：
2.6
通讯作者：
Jinou Zheng
中科院分区：
文献类型：
--
作者：
Zhao Zhang;Xia Zhou;Jinping Liu;Lu Qin;Lu Yu;Xiaomin Pang;Wei Ye;Jinou Zheng
在这项研究中，我们的目的是检测纵向变化的局部自发脑活动和默认模式网络（DMN）的功能连接（FC）的颞叶癫痫（TLE）患者超过两年的随访。我们使用低频波动幅度（ALFF）分析和独立成分分析（伊卡）来探讨局部自发脑活动和FC强度的差异。本研究共招募了33名参与者（16名TLE患者和17名年龄和性别匹配的健康对照（HC））。所有参与者进行注意力网络测试（ANT）的执行控制功能的评价。与基线时的健康患者相比，随访时TLE患者在DMN内表现出左额内侧回的ALFF值增加，以及左顶下回（IPG）的FC值减少。TLE患者显示执行功能障碍，但在随访期间没有观察到进行性恶化。这项研究揭示了异常分布的ALFF值和Rs-FC的变化超过两年的随访期在TLE，这两个表现出不同的重组轨迹和效率的损失。
In this study, we aimed to detect longitudinal alterations in local spontaneous brain activity and functional connectivity (FC) of the default mode network (DMN) in patients with temporal lobe epilepsy (TLE) over a two-year follow-up. We used amplitude of low-frequency fluctuation (ALFF) analysis and independent component analysis (ICA) to explore differences in local spontaneous brain activity and FC strength. In total, 33 participants (16 patients with TLE and 17 age- and gender-matched healthy controls (HCs)) were recruited in this study. All participants performed the Attention Network Test (ANT) for evaluation of the executive control function. Compared with healthy patients at baseline, patients with TLE at follow-up exhibited increased ALFF values in the left medial frontal gyrus, as well as reduced FC values in the left inferior parietal gyrus (IPG) within the DMN. Patients with TLE revealed executive dysfunction, but no progressive deterioration was observed during follow-up. This study revealed the abnormal distribution of ALFF values and Rs-FC changes over a two-year follow-up period in TLE, both of which demonstrated different reorganization trajectories and loss of efficiency.