Absence of the kdr mutation in the molecular 'M' form suggests different pyrethroid resistance mechanisms in the malaria vector mosquito Anopheles gambiae s.s.
Absence of the kdr mutation in the molecular 'M' form suggests different pyrethroid resistance mechanisms in the malaria vector mosquito Anopheles gambiae s.s.
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DOI：
10.1046/j.1365-3156.2003.01034.x
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发表时间：
2003-05-01
影响因子：
3.3
通讯作者：
Coetzee, M
中科院分区：
文献类型：
--
作者：
Awolola, TS;Brooke, BD;Coetzee, M
在尼日利亚西南部使用世卫组织标准程序、诊断试剂盒和试纸对成年按蚊进行的现场试验显示，严格感冈比亚按蚊成年种群对拟除虫菊酯（溴氰菊酯和氯菊酯）具有抗药性。与拟除虫菊酯抗性有关的敲除抗性（kdr）突变仅在An的分子S形式中发现。冈比亚虫甚至在分子M和S形态同时发生的地区也存在。在M型中没有kdr突变表明在an中存在另一种拟除虫菊酯抗性机制。冈比亚按蚊的轮上。
Field tests conducted on adult Anopheles mosquitoes using standard WHO procedures, diagnostic kits and test papers in south-western Nigeria showed pyrethroid (deltamethrin and permethrin) resistance in adult populations of Anopheles gambiae sensu stricto. The knock-down resistance (kdr) mutation involved in pyrethroid resistance was only found in the molecular S form of An. gambiae s.s. even in area where both molecular M and S forms occurred in sympatry. The absence of the kdr mutation in the M form suggests an additional pyrethroid resistance mechanism in An. gambiae s.s.