Disruptions to routine childhood vaccinations in low- and middle-income countries during the COVID-19 pandemic: A systematic review.
Disruptions to routine childhood vaccinations in low- and middle-income countries during the COVID-19 pandemic: A systematic review.
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DOI：
10.3389/fped.2022.979769
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发表时间：
2022
影响因子：
2.6
通讯作者：
Whittaker, Elizabeth
中科院分区：
文献类型：
--
作者：
Cardoso Pinto, Alexandra M.;Ranasinghe, Lasith;Dodd, Peter J.;Budhathoki, Shyam Sundar;Seddon, James A.;Whittaker, Elizabeth
新冠肺炎大流行扰乱了全球儿童常规疫苗接种，受影响最大的是低收入和中等收入国家。这项研究旨在量化LMICs常规疫苗接种的中断程度。2022年2月11日，对MEDLINE、Embase、Global Health、CINAHL、Scope us和MedRxiv进行了系统评价(Propero CRD42021286386)。如果报告了2020年3月之前和之后的儿科常规疫苗接种水平，则包括从2020年1月起发表的初步研究。使用NHLBI横断面研究工具进行研究评估。使用中位数和四分位数范围对干扰程度进行总结。总共确定了39项横断面研究。这些数据显示，在所有疫苗中，−总体相对中位数下降了10.8%[四分位数范围内−下降27.6%，−下降1.4%]。中上收入国家(−14.3%；IQR−24.3%，−2.4%)和低收入国家(−18.0%；IQR−48.6%，−4.1%)的降幅比低收入国家(−3.1%；IQR−12.8%，2.9%)更大，出生时接种的疫苗(−11.8%；IQR−27.7%，−3.5%)与出生后接种(−8.0%；IQR−28.6%，−0.4%)。与基线相比，大流行前3个月的降幅(−8.1%；IQR−35.1%，−1.4%)大于2020年剩余时间(−3.9%；IQR−13.0%，11.4%)。儿科常规疫苗接种有所下降，在MICs和出生时接种疫苗的下降最大。各国必须在发布公共卫生信息的同时，优先考虑追赶项目，以鼓励接种疫苗。标识：CRD42021286386。
The COVID-19 pandemic has disrupted routine childhood vaccinations worldwide with low- and middle-income countries (LMICs) most affected. This study aims to quantify levels of disruption to routine vaccinations in LMICs. A systematic review (PROSPERO CRD42021286386) was conducted of MEDLINE, Embase, Global Health, CINAHL, Scopus and MedRxiv, on the 11th of February 2022. Primary research studies published from January 2020 onwards were included if they reported levels of routine pediatrics vaccinations before and after March 2020. Study appraisal was performed using NHLBI tool for cross-sectional studies. Levels of disruption were summarized using medians and interquartile ranges. A total of 39 cross-sectional studies were identified. These showed an overall relative median decline of −10.8% [interquartile range (IQR) −27.6%, −1.4%] across all vaccines. Upper-middle-income countries (upper-MICs) (−14.3%; IQR −24.3%, −2.4%) and lower-MICs (−18.0%; IQR −48.6%, −4.1%) showed greater declines than low-income countries (−3.1%; IQR −12.8%, 2.9%), as did vaccines administered at birth (−11.8%; IQR −27.7%, −3.5%) compared to those given after birth (−8.0%; IQR −28.6%, −0.4%). Declines during the first 3 months of the pandemic (−8.1%; IQR −35.1%, −1.4%) were greater than during the remainder of 2020 (−3.9%; IQR −13.0%, 11.4%) compared to baseline. There has been a decline in routine pediatric vaccination, greatest in MICs and for vaccines administered at birth. Nations must prioritize catch-up programs alongside public health messaging to encourage vaccine uptake. Identifier: CRD42021286386.
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