CYTOSKELETON PLASMA-MEMBRANE INTERACTIONS
CYTOSKELETON PLASMA-MEMBRANE INTERACTIONS
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DOI：
10.1126/science.1439807
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发表时间：
1992-11-06
期刊：
影响因子：
56.9
通讯作者：
HITT, AL
中科院分区：
文献类型：
--
作者：
LUNA, EJ;HITT, AL
位于细胞骨架和质膜之间的蛋白质控制细胞的形状，划定特定的膜域，并稳定与其他细胞和底物的附着。这些蛋白质还调节细胞运动和细胞质对生长因子和其他外界刺激的反应。这种细胞功能的多样性与大量的生化机制相匹配，这些生化机制介导了膜蛋白和底层细胞骨架(即所谓的膜骨架)之间的连接。通过对这种生化多样性的考察，一般的组织主题开始浮出水面。
Proteins at the boundary between the cytoskeleton and the plasma membrane control cell shape, delimit specialized membrane domains, and stabilize attachments to other cells and to the substrate. These proteins also regulate cell locomotion and cytoplasmic responses to growth factors and other external stimuli. This diversity of cellular functions is matched by the large number of biochemical mechanisms that mediate the connections between membrane proteins and the underlying cytoskeleton, the so-called membrane skeleton. General organizational themes are beginning to emerge from examination of this biochemical diversity.