Risk factors for thrombosis in lupus patients.
Risk factors for thrombosis in lupus patients.
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狼疮患者血栓形成的危险因素。
DOI：
10.1136/ard.48.11.933
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发表时间：
1989
影响因子：
27.4
通讯作者：
P. G. D. Groot
中科院分区：
文献类型：
--
作者：
P. Hasselaar;R. Derksen;L. Blokzijl;M. Hessing;H. Nieuwenhuis;Barend Bouma;P. G. D. Groot
对 74 名狼疮患者（58 名患有系统性红斑狼疮；16 名患有狼疮样疾病）的狼疮抗凝剂、抗心磷脂抗体浓度、抗凝血酶 III、纤溶酶原、（游离）蛋白 S、蛋白 C、凝血酶原、血小板计数和出血时间进行了测定，以确定这些患者是否存在血栓形成的危险因素。在评估的变量中，狼疮抗凝物与血栓形成史的相关性最强。抗心磷脂抗体阳性浓度和（轻度）血小板减少症的存在均与血栓形成史和狼疮抗凝剂的存在显着相关。在一些患者中发现抗凝血酶 III、纤溶酶原、（游离）蛋白 S 和蛋白 C 浓度降低，但与血栓形成或狼疮抗凝物无关。患有血栓的患者的总蛋白S平均浓度显着低于未服用狼疮抗凝剂的患者，并且服用狼疮抗凝剂的患者也显着低于未服用狼疮抗凝剂的患者。 3/74 (4%) 狼疮患者的凝血酶原抗原浓度降低。这三名患者服用了狼疮抗凝剂，但没有血栓形成史，这表明低凝血酶原浓度可以保护服用狼疮抗凝剂的患者免于血栓形成。出血时间延长与狼疮抗凝物的存在相关，但与血栓形成史无关。逐步逻辑回归分析未揭示使用狼疮抗凝剂的狼疮患者血栓形成的其他危险因素。狼疮患者经常发现抗凝血酶 III 浓度升高和游离蛋白 S 浓度降低，与狼疮抗凝剂或血栓形成无关。
Lupus anticoagulant, concentrations of anticardiolipin antibodies, antithrombin III, plasminogen, (free) protein S, protein C, prothrombin, platelet counts, and bleeding times were determined in 74 lupus patients (58 with systemic lupus erythematosus; 16 with lupus-like disease) to establish the presence of risk factors for thrombosis in these patients. Of the variables evaluated, lupus anticoagulant had the strongest association with a history of thrombosis. Both positive anticardiolipin antibody concentrations and the presence of (mild) thrombocytopenia were significantly associated with a history of thrombosis and the presence of lupus anticoagulant. Reduced concentrations of antithrombin III, plasminogen, (free) protein S, and protein C were found in some patients but were not associated with either thrombosis or lupus anticoagulant. Mean concentrations of total protein S were significantly lower in patients with thrombosis than in those without and in patients with lupus anticoagulant than in those without. The antigenic concentration of prothrombin was reduced in 3/74 (4%) lupus patients. These three patients had lupus anticoagulant but no history of thrombosis, which suggests that a low prothrombin concentration protects patients with lupus anticoagulant from the development of thrombosis. A prolonged bleeding time was associated with the presence of lupus anticoagulant but not with a history of thrombosis. Analysis by stepwise logistic regression did not disclose additional risk factors for thrombosis in lupus patients with lupus anticoagulant. Increased antithrombin III concentrations and decreased free protein S concentrations are often found in lupus patients, unrelated to lupus anticoagulant or thrombosis.
影响因子：
20.3
作者：
Rebecca A. Fleck;S. Rapaport;Vijaya Mohan Rao
通讯作者：
Rebecca A. Fleck;S. Rapaport;Vijaya Mohan Rao
功能性蛋白S缺乏时会出现蛋白S的血浆分布异常。
影响因子：
20.3
作者：
Comp,PC;Doray,D;Patton,D;Esmon,CT
通讯作者：
Esmon,CT
影响因子：
158.5
作者：
COMP, PC;ESMON, CT
通讯作者：
ESMON, CT