Expression of APOBEC2 is transcriptionally regulated by NF-κB in human hepatocytes
Expression of APOBEC2 is transcriptionally regulated by NF-κB in human hepatocytes
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DOI：
10.1016/j.febslet.2005.12.081
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发表时间：
2006-02-06
期刊：
影响因子：
3.5
通讯作者：
Chiba, T
中科院分区：
文献类型：
--
作者：
Matsumoto, T;Marusawa, H;Chiba, T
载脂蛋白 B mRNA 编辑酶催化亚基 2 (APOBEC2) 是核酸编辑酶的一员。然而，APOBEC2的生理功能仍不清楚。我们证明 APOBEC2 表达在肿瘤坏死因子-a (TNF-α) 和白介素-1 β 的作用下显着增强。抑制 NF-κ B 激活总是会阻断 TNF-α 诱导的 APOBEC2 表达。 APOBEC2 的启动子区在基因 5' 非翻译区 -625/-616 处包含功能性 NF-κ B 反应元件。这些结果表明 APOBEC2 表达受到促炎细胞因子通过 NF-κ B 激活的调节，并表明 APOBEC2 在肝脏炎症的病理生理学中可能发挥作用。 (c) 2005 年欧洲生化学会联合会。由 Elsevier B.V. 出版。保留所有权利。
Apolipoprotein B mRNA-editing enzyme catalytic subunit 2 (APOBEC2) is a member of the nucleic-acid-editing enzymes. However, the physiological function of APOBEC2 remains unclear. We demonstrate that APOBEC2 expression is strongly enhanced in response to both tumour necrosis factor-a (TNF-alpha) and interleukin-1 beta. Inhibition of NF-kappa B activation invariably blocks TNF-alpha-induced APOBEC2 expression. The promoter region of APOBEC2 contains functional NF-kappa B response elements in the 5' untranslated region of the gene at -625/-616. These results show that APOBEC2 expression is regulated by pro-inflammatory cytokines via NF-kappa B activation and suggest a possible role of APOBEC2 in the pathophysiology of hepatic inflammation. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.