CTA Characteristics of the Circle of Willis and Intracranial Aneurysm in a Chinese Crowd with Family History of Stroke.
CTA Characteristics of the Circle of Willis and Intracranial Aneurysm in a Chinese Crowd with Family History of Stroke.
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中国有脑卒中家族史人群Willis环和颅内动脉瘤的CTA特征
DOI：
10.1155/2016/1743794
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发表时间：
2016
影响因子：
--
通讯作者：
Yang XY
中科院分区：
文献类型：
--
作者：
Jin ZN;Dong WT;Cai XW;Zhang Z;Zhang LT;Gao F;Kang XK;Li J;Wang HN;Gao NN;Ning XJ;Tu J;Li FT;Zhang J;Jiang YJ;Li NX;Yang SY;Zhang JN;Wang JH;Yang XY
背景和目的。有卒中家族史人群的血管形态尚不清楚。本研究阐明了有中风家族史的受试者的颅内血管特点和颅内动脉瘤的患病率。方法：研究方法。采用分层整群随机抽样方法，对天津蓟县、中国等地农村居民进行卒中家族史调查。所有受试者都接受了体格检查、头部计算机断层扫描(CT)和头部和颈部计算机断层血管成像(CTA)扫描。分析了该人群中Willis环和脑血管疾病的解剖变异。结果。在生活环境相似、遗传背景稳定、有卒中家族史且无明显神经功能损害的人群中，A1节段发育不良或缺失的性别差异有统计学意义(男9.8%，女18.8%，p=0.031)，尤其是右侧A1段发育不良或缺失差异显著(男5.9%，女16.4%，p=0.004)。(2)双侧后交通动脉发育不良或缺失男性多于女性(58.2%vs45.3%，p=0.032)。单侧胎儿大脑后动脉的发生率女性高于男性(17.2%比8.5%，p=0.028)。(3)奶牛不完整的比例不随年龄增长而显著增加。与健康的中国人相比，人群中不完整奶牛的比例更高(P<；0.001)。(4)危险因素与奶牛发病无明显相关性。(5)特殊人群动脉瘤患病率为10.3%。结论。在有中风家族史的人群中，奶牛的某些变异与性别有关，但与年龄无关。循环不完整可能是独立于卒中常见危险因素的危险因素，在有卒中家族史的人群中倾向于导致脑缺血。与其他人群相比，本研究对象的颅内动脉瘤患病率相对较高。
Background and Purpose. The vascular morphology in crowd with family history of stroke remains unclear. The present study clarified the characteristics of the intracranial vascular CoW and prevalence of intracranial aneurysms in subjects with family history of stroke. Methods. A stratified cluster, random sampling method was used for subjects with family history of stroke among rural residents in Jixian, Tianjin, China. All the subjects underwent a physical examination, head computed tomography (CT) scan, and cephalic and cervical computed tomography angiography (CTA) scan. Anatomic variations in the Circle of Willis and cerebrovascular disease in this population were analyzed. Results. In the crowd with similar living environment, stable genetic background, and family history of stroke and without obvious nerve function impairment (1) hypoplasia or absence of A1 segment was significantly different in gender (male versus female: 9.8% versus 18.8%, p = 0.031), especially the right-side A1 (male versus female: 5.9% versus 16.4%, p = 0.004). (2) Hypoplasia or absence of bilateral posterior communicating arteries was more common in men than women (58.2% versus 45.3%, p = 0.032). Unilateral fetal posterior cerebral artery was observed more often in women than men (17.2% versus 8.5%, p = 0.028). (3) The percentage of subjects with incomplete CoW did not increase significantly with age. Compared to healthy Chinese people, the crowd had a higher percentage of incomplete CoW (p < 0.001). (4) No obvious correlation between risk factors and CoW was found. (5) The prevalence of aneurysm was 10.3% in the special crowd. Conclusions. The certain variations of CoW showed significant relation to gender, but not to age in people with family history of stroke. The incomplete circle may be a dangerous factor that is independent of common risk factors for stroke and tend to lead to cerebral ischemia in the crowd with family history of stroke. The prevalence of intracranial aneurysm is comparatively high in the present subjects compared to other people.