Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study.
Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study.
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DOI：
10.1155/2015/962046
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发表时间：
2015
影响因子：
4
通讯作者：
Abdul Gafor AH
中科院分区：
文献类型：
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作者：
Alharazy S;Kong NC;Mohd M;Shah SA;Ba'in A;Abdul Gafor AH
Objective.这项纵向研究旨在确定活检证实的狼疮性肾炎（LN）患者在肾脏疾病活动的不同阶段的尿单核细胞趋化蛋白-1（uMCP-1）水平，并将其与目前的标准标志物进行比较。方法. LN患者（活动或非活动）在基线、2个月和4个月时测量其uMCP-1水平和标准疾病活动标记物。分析尿液参数、肾功能检查、血清学标志物和肾脏SLE疾病活动指数-2K（肾脏SLEDAI-2K）以确定其与uMCP-1的相关性。结果100名患者完成了研究。在每次就诊时，uMCP-1水平（pg/mg肌酐）在活性组中显著更高，尤其是在复发时，并且与蛋白尿和肾SLEDAI-2K显著相关。受试者工作特征（ROC）曲线显示uMCP-1是LN的潜在生物标志物。而多因素Logistic回归分析显示，只有尿蛋白和血清白蛋白是LN活动的独立预测因子，而uMCP-1不是。结论uMCP-1在活动期LN中表达增高。虽然uMCP-1不是LN活动性的独立预测因子，但在临床诊断尤其是早期复发尚不明确时，它可作为一个预测指标。需要进行更大规模和更长时间的研究。
Objective. This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Patients with LN—active or inactive—had their uMCP-1 levels and standard disease activity markers measured at baseline and 2 and 4 months. Urinary parameters, renal function test, serological markers, and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uMCP-1. Results. A hundred patients completed the study. At each visit, uMCP-1 levels (pg/mg creatinine) were significantly higher in the active group especially with relapses and were significantly associated with proteinuria and renal SLEDAI-2K. Receiver operating characteristic (ROC) curves showed that uMCP-1 was a potential biomarker for LN. Whereas multiple logistic regression analysis showed that only proteinuria and serum albumin and not uMCP-1 were independent predictors of LN activity. Conclusion. uMCP-1 was increased in active LN. Although uMCP-1 was not an independent predictor for LN activity, it could serve as an adjunctive marker when the clinical diagnosis of LN especially early relapse remains uncertain. Larger and longer studies are indicated.