Lesion pattern in patients with multiple sclerosis and depression
Lesion pattern in patients with multiple sclerosis and depression
复制标题
DOI：
10.1177/135245850000600304
复制
发表时间：
2000-06-01
影响因子：
5.8
通讯作者：
Becker, G
中科院分区：
文献类型：
--
作者：
Berg, D;Supprian, T;Becker, G
为了评估是否可以在抑郁性多发性硬化症 (MS) 患者中发现原发性抑郁症和与神经退行性疾病相关的抑郁症中所见的基底边缘系统的特定病变模式或变化，我们对 78 名 MS 患者进行了 MRI 检查，包括对病变和脑桥中脑中线（中缝）的高信号进行定量测量。此外，还进行了脑桥中脑中线的松弛测量、半定量评价其回声性的经颅超声检查以及标准化的神经学、神经精神病学和神经心理学评估。 31 名患者符合 DSM-IV 抑郁症标准。抑郁型多发性硬化症患者的颞部病变负荷明显大于非抑郁型多发性硬化症患者，尤其是右侧。右顶叶、右额叶、小脑的病变和总病变负荷检测到差异趋势。组间脑桥中脑中线水平区域的高信号、松弛测量和回声均无显着差异。我们得出的结论是，多发性硬化症患者的抑郁症与帕金森病或单相抑郁症中所见的脑干基底边缘系统的改变无关，但与基底边缘系统投影区域的病变负荷增加有关。
To assess if a specific lesion pattern or changes of the basal limbic system as seen in primary depression and depression associated with neurodegenerative disorders might be identified in depressive multiple sclerosis (MS) patients, we submitted 78 MS patients to a MRI examination consisting of a quantitative measurement of lesions and of hyperintense signals from the pontomesencephalic midline (raphe). Furthermore relaxometry of the pontomesencephalic midline, a transcranial ultrasound examination rating its echogenicity semiquantitatively and a standardized neurological, neuropsychiatric and neuropsychological assessment were obtained. Thirty-one patients fulfilled the DSM-IV criteria for depression. Depressed MS patients had a significantly larger temporal lesion load than non-depressed MS patients, especially on the right side. A trend of difference was detected for lesions of the right parietal lobe, the right frontal lobe, the cerebellum and the total lesion load. Neither hyperintense signals or relaxometry nor echogenicity of the region at the level of the pontomesencephalic midline were significantly different between the groups. We conclude that depression in MS patients is not associated with on alteration of the basal limbic system at the brainstem as seen in Parkinson's disease or unipolar depression but with on increased lesion load of the projection areas of the basal limbic system.