ANALGESIC ANTIPYRETIC DRUGS AS ANTAGONISTS OF BRADYKININ
ANALGESIC ANTIPYRETIC DRUGS AS ANTAGONISTS OF BRADYKININ
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DOI：
10.1111/j.1476-5381.1960.tb00288.x
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发表时间：
1960-01-01
期刊：
影响因子：
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通讯作者：
SHORLEY, PG
中科院分区：
文献类型：
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作者：
COLLIER, HOJ;SHORLEY, PG
定量检测解热镇痛药与缓激肽的拮抗作用。利用豚鼠在体的支气管收缩反应。50倍的乙酰水杨酸盐拮抗缓激肽，但不能改变小剂量组胺、5-羟色胺或乙酰胆碱引起的收缩。苯丁酮、氨基比林和非那酮也有较强的抗缓激肽活性，而阿司匹林、氨基比林和苯丁酮则没有。拮抗缓激肽对豚鼠体内皮肤毛细血管、豚鼠回肠毛细血管或大鼠十二指肠毛细血管的作用。报道了其他解热、止痛或抗炎药物的抗缓激肽活性。
The antagonism between analgesic antipyretic drugs and bradykinin was examined quant. using the bronchoconstrictor response of guinea-pigs in vivo. 50 times the quantity of acetylsalicylate which just antagonised bradykinin did not modify the constriction due to small doses of histamine, 5HT, or ACh. Phenylbutazone, amidopyrine, and phenazone also had high anti-bradykinin potency but aspirin, amidopyrine and phenylbutazone did not sp. antagonise the action of bradykinin on capillaries of the guinea-pig skin in vivo, on the guinea-pig ileum, or on the rat duodenum in vitro. The antibradykinin potencies of other antipyretic analgesic or anti-inflammatory drugs are reported.