Start-specific transcription in yeast.
Start-specific transcription in yeast.
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DOI：
10.1007/978-3-642-79910-5_5
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发表时间：
1996
影响因子：
--
通讯作者：
L. Breeden
中科院分区：
文献类型：
--
作者：
L. Breeden
在发芽酵母细胞周期的G1期到S期，至少有30个不同基因的转录爆发。这在一定程度上可能是因为酿酒酵母经常作为一种群体微生物存在，它的大部分时间都在固定相(G0)。当细胞有机会进入有丝分裂细胞周期时，可以快速有效地开始分裂的细胞具有选择性优势。因此，它们重新合成对DNA的高保真复制至关重要的酶，并取代其他可能在G0长期停滞中幸存下来的成分也就不足为奇了。负责启动细胞周期的蛋白质，特别是那些如果在细胞周期的其他阶段产生会扰乱细胞周期的蛋白质，专门在G1/S转换时转录。大多数G1周期蛋白是在这个时候特异表达的，它们的活性决定了G1/S转换的时间(Richardsonet al.1989年；Nashet al.1988年；交叉1988年)。
At the G1to S transition of the budding yeast cell cycle there is burst of transcription of at least 30 different genes. This may in part be due to the fact thatSaccheromyes cerevisiaeoften exists as a colonial micro-organism which spends most of its time in stationary phase (G0). When cells have the opportunity to enter the mitotic cell cycle, there is a selective advantage for cells that can start dividing rapidly and efficiently. Thus it is not surprising that they resynthesize enzymes critical for high-fidelity replication of DNA and replace other components that may not have survived extended G0arrest. Proteins that are responsible for starting the cell cycle, particularly those that would disrupt the cycle if they were produced at other stages of the cell cycle, are transcribed specifically at the G1/S transition. Most of the G1cyclins are expressed specifically at this time, and their activity determines the timing of the G1/S transition (Richardsonet al. 1989;Nashet al. 1988;Cross1988).