Regulation of the spermatogonial stem cell niche.

Regulation of the spermatogonial stem cell niche.
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DOI:
10.1111/j.1439-0531.2008.01189.x
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发表时间:
2008-07
期刊:
Reproduction in domestic animals = Zuchthygiene
影响因子:
--
通讯作者:
Hofmann MC
Hofmann MC
中科院分区:
其他
文献类型:
--
作者:
Kostereva N;Hofmann MC

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Spermatogonial stem cells (SSCs) reside within specialized microenvironments called ‘niches’, which are essential for their maintenance and self-renewal. In the mammalian testis, the main components of the niche include the Sertoli cell, the growth factors that this nursing cell produces, the basement membrane, and stimuli from the vascular network between the seminiferous tubules. This review focuses on signalling pathways maintaining SSCs self-renewal and differentiation and describes potential mechanisms of regulation of the spermatogonial stem cell niche.
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