Prostate-specific membrane antigen as a marker of pancreatic cancer cells
Prostate-specific membrane antigen as a marker of pancreatic cancer cells
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前列腺特异性膜抗原作为胰腺癌细胞的标志物
DOI：
10.1007/s12032-014-0857-z
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发表时间：
2014-03-01
期刊：
影响因子：
3.4
通讯作者：
Hao, Jihui
中科院分区：
文献类型：
--
作者：
Ren, He;Zhang, Huan;Hao, Jihui
本研究旨在检测胰腺癌患者前列腺特异性膜抗原（prostate-specific membrane antigen， PSMA）的表达，并分析PSMA与临床特征的相关性。采用免疫组织化学和实时定量聚合酶链反应分别检测胰腺癌组织、胰腺上皮内瘤变组织和正常胰腺组织中PSMA蛋白和mRNA的表达。并对患者的临床特点及预后进行分析。PSMA蛋白和mRNA水平均在胰腺癌细胞中表达。此外，PSMA水平与胰腺导管腺癌患者的预后相关。PSMA高表达胰腺癌患者的总生存时间明显短于低表达胰腺癌患者。此外，PSMA水平与临床病理特征相关，包括组织学分级和病理肿瘤-淋巴结转移分期。PSMA参与胰腺癌的癌变过程，可能成为胰腺癌的潜在治疗靶点。
The aim of this study was to identify the expression of prostate-specific membrane antigen (PSMA) and analyze the correlation between PSMA with clinical characteristics in patients with pancreatic cancer. The expression of PSMA protein and mRNA was detected by immunohistochemistry and real-time quantitative polymerase chain reaction in pancreatic cancer tissues, pancreatic intraepithelial neoplasia or normal pancreatic tissues, respectively. And clinical characteristics and prognosis of patients were investigated. PSMA was expressed in pancreatic cancer cells, both in protein and mRNA levels. Moreover, the PSMA levels were associated with the prognosis of patients with pancreatic ductal adenocarcinoma. The overall survival time of pancreatic cancer patients with high expression of PSMA was significantly shorter than that of the low ones. Moreover, the PSMA levels were correlated with clinicopathological features including the histological grade and pathological tumor-node-metastasis stage. PSMA is involved in the carcinogenesis of pancreatic cancer, and it might serve as a potential therapeutic target for pancreatic cancer.