Requirement for CD44 in activated T cell extravasation into an inflammatory site
Requirement for CD44 in activated T cell extravasation into an inflammatory site
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DOI：
10.1126/science.278.5338.672
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发表时间：
1997-10-24
期刊：
影响因子：
56.9
通讯作者：
Siegelman, MH
中科院分区：
文献类型：
--
作者：
DeGrendele, HC;Estess, P;Siegelman, MH
白细胞通过白细胞和内皮细胞之间的互补配体相互作用从血液中渗出到炎症部位，T细胞的激活增加了它们与透明质酸（HA）的结合，并使cd44介导的原发性粘附（滚动）成为可能。这种滚动可以在小鼠V(β)8(+) T细胞对特异性超抗原刺激的体内诱导；它最初在淋巴结中发现，然后在外周血中发现，最后在腹膜中发现，这是最初的炎症部位。抑制研究表明，V(β)8（+）细胞向腹腔的迁移依赖于CD44和HA。因此，CD44-HA相互作用可以将淋巴细胞靶向到特定的淋巴外效应位点。
Leukocytes extravasate from the blood into inflammatory sites through complementary ligand interactions between leukocytes and endothelial cells, Activation of T cells increases their binding to hyaluronate (HA) and enables CD44-mediated primary adhesion (rolling). This rolling could be induced in vivo in murine V(beta)8(+) T cells in response to specific superantigen stimulation; it was initially found in lymph nodes, then in peripheral blood, and finally within the peritoneum, the original inflamed site. The migration of V(beta)8(+) cells into the peritoneal cavity was dependent on CD44 and HA, as shown by inhibition studies. Thus, CD44-HA interactions can target lymphocytes to specific extralymphoid effector sites.