Extended exposure to dietary melatonin reduces tumor number and size in aged male mice.
Extended exposure to dietary melatonin reduces tumor number and size in aged male mice.
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DOI：
10.1016/j.exger.2010.09.004
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发表时间：
2011-01
影响因子：
3.9
通讯作者：
Bondy, Stephen C.
中科院分区：
文献类型：
--
作者：
Sharman, Edward H.;Sharman, Kaizhi G.;Bondy, Stephen C.
在为期九年的一系列实验中，几组雄性小鼠被给予饮食褪黑激素。总体而言，与年龄相似的对照动物相比，处死时年龄≥26个月的补充褪黑激素的小鼠的肿瘤显著较少，严重程度较低。这些研究最初是为了探索这种药物降低大脑衰老的一些遗传指标的发病率的潜力。处死这些动物时，常规检查肿瘤的明显证据，发现肿瘤时，记录其发生情况及其大小。肿瘤通常在几种小鼠的衰老过程中发现。由于肿瘤发生不是本研究的初衷，因此记录了这些观察结果，但未进行更详细的追踪。本报告对这些数据进行了整理和总结。这种分析的缺点是没有记录肿瘤的起源和形态。然而，该研究也具有在许多动物组中进行较长时间的优势。因此，许多可能是潜在混杂因素的外来因素，如季节或饮食变化，不太可能干扰分析。使用一种以上的小鼠品系加强了这些发现可能具有普遍相关性的可能性。老年和年轻动物都包括在原始实验中，但小于25个月的动物的肿瘤发病率非常低。
Several sets of male mice were given dietary melatonin over a series of experiments performed during a nine year period. Overall, melatonin-supplemented mice aged ≥26 months at sacrifice had significantly fewer tumors with lower severity than similarly aged control animals. The studies were originally designed to explore the potential of this agent for reducing the rate of onset of some genetic indices of brain aging. When these animals were sacrificed they were routinely examined for overt evidence of tumors and when these were found, a note was made of their occurrence, and of their size. Tumors are commonly found during senescence of several strains of mice. Since tumorigenesis was not the original intent of the study, these observations were recorded but not pursued in greater detail. In this report, these data have now been collated and summarized. This analysis has the disadvantage that tumor origin and morphology were not recorded. However, the study also has the advantage of being conducted over an extended period of time with many groups of animals. In consequence, many extraneous factors, which could be potential confounders, such as seasonal or dietary variations, are unlikely to have interfered with the analysis. The use of more than one mouse strain strengthens the possibility that the findings may have general relevance. Both aged and young animals were included in the original experiments but the tumor incidence in animals younger than 25 months was very low.
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