Applications of Acoustofluidics in Bioanalytical Chemistry
Applications of Acoustofluidics in Bioanalytical Chemistry
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DOI：
10.1021/acs.analchem.8b03786
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发表时间：
2019-01-01
影响因子：
7.4
通讯作者：
Huang, Tony Jun
中科院分区：
文献类型：
--
作者：
Li, Peng;Huang, Tony Jun
声学具有广泛的应用范围，从噪声消除到超声成像。在过去的十年中，人们对开发用于生物和生物医学应用的基于声学的方法越来越感兴趣。本文综述了声流方法的最新进展（即，声学和微流体的融合）到生物分析化学。我们描述了声流控技术的概念，以及它如何能够适应不同类型的生物分析应用，包括样品浓缩，荧光激活细胞分选，无标记细胞/颗粒分离和流体操作。每个应用程序的例子，这些方法的优点和局限性进行了讨论。最后，我们的观点，发展解决方案，应采取的方向，以解决生物分析化学中的声流控应用的瓶颈。
Acoustics has a broad spectrum of applications, ranging from noise cancelation to ultrasonic imaging. In the past decade, there has been increasing interest in developing acoustic-based methods for biological and biomedical applications. This Perspective summarizes the recent progress in applying acoustofluidic methods (i.e., the fusion of acoustics and microfluidics) to bioanalytical chemistry. We describe the concepts of acoustofluidics and how it can be tailored to different types of bioanalytical applications, including sample concentration, fluorescence-activated cell sorting, label-free cell/particle separation, and fluid manipulation. Examples of each application are given, and the benefits and limitations of these methods are discussed. Finally, our perspectives on the directions that developing solutions should take to address the bottlenecks in the acoustofluidic applications in bioanalytical chemistry are presented.