Transdermal immunization with large proteins by means of ultradeformable drug carriers
Transdermal immunization with large proteins by means of ultradeformable drug carriers
复制标题
DOI：
10.1002/eji.1830251248
复制
发表时间：
1995-12
影响因子：
5.4
通讯作者：
Amla Paul;G. Cevc;Bemal K. Bachhawat
中科院分区：
文献类型：
--
作者：
Amla Paul;G. Cevc;Bemal K. Bachhawat
通过称为传递体的新型、超变形和自优化的试剂载体，大分子可以通过完整的渗透屏障进入体内。这允许通过正常皮肤进行非侵入性免疫，并产生与皮下注射相同免疫原制剂相似或甚至略高的抗体滴度。前一种类型的免疫也导致血液中比重复免疫原注射更高的伊加/IgG比率，如本文所示的可溶性蛋白质人血清白蛋白以及小鼠中的整合膜蛋白质间隙连接蛋白。
By means of novel, ultradeformable and self‐optimizing agent carriers called transfersomes, large molecules can be brought into the body through intact permeability barriers. This permits non‐invasive immunization through normal skin and gives rise to a similar or even slightly higher antibody titer than subcutaneous injections of the same immunogen formulation. The former type of immunization also results in a higher IgA/IgG ratio in the blood than the repeated immunogen injections, as shown here for a soluble protein, human serum albumin, as well as for an integral membrane protein, gap junction protein, in mice.