9.4T human MRI: Preliminary results
9.4T human MRI: Preliminary results
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DOI：
10.1002/mrm.21073
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发表时间：
2006-12-01
影响因子：
3.3
通讯作者：
Ugurbil, Kamil
中科院分区：
文献类型：
--
作者：
Vaughan, Thomas;DelaBarre, Lance;Ugurbil, Kamil
这项工作报告了在新的高场基准9AT上的第一个人类图像的初步结果。将直径为65 cm的孔磁体与直径为40 cm的不对称头部梯度和垫片组一起使用。一个多通道传输线（横向电磁（TEM））头部线圈驱动的可编程并行收发器，以控制每个通道的相对相位和幅度独立。这些新的RF场控制方法有助于补偿归因于相消干涉图案的RF伪影，以实现均匀的9AT头部图像或定位解剖目标。在FDA试验用器械豁免（IDE）和内部审查委员会（IRB）批准的人体研究之前，对猪模型进行了初步射频安全性研究。这些数据与前44名人类志愿者的离职面谈结果一起报告。虽然有几点改进进行了讨论，初步结果表明，安全和成功的人体成像在9AT的可行性。
This work reports the preliminary results of the first human images at the new high-field benchmark of 9AT. A 65-cm diameter bore magnet was used together with an asymmetric 40-cm-diameter head gradient and shim set. A multichannel transmission line (transverse electromagnetic (TEM)) head coil was driven by a programmable parallel transceiver to control the relative phase and magnitude of each channel independently. These new RF field control methods facilitated compensation for RF artifacts attributed to destructive interference patterns, in order to achieve homogeneous 9AT head images or localize anatomic targets. Prior to FDA investigational device exemptions (IDEs) and internal review board (IRB)-approved human studies, preliminary RF safety studies were performed on porcine models. These data are reported together with exit interview results from the first 44 human volunteers. Although several points for improvement are discussed, the preliminary results demonstrate the feasibility of safe and successful human imaging at 9AT.