Optofluidic waveguides: I. Concepts and implementations
Optofluidic waveguides: I. Concepts and implementations
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DOI：
10.1007/s10404-007-0199-7
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Hawkins, Aaron R.
中科院分区：
文献类型：
--
作者：
Schmidt, Holger;Hawkins, Aaron R.
本文综述了液芯光波导在光流变学中的最新发展和研究现状，重点介绍了液芯光波导在建立全平面光流控芯片实验室中的适用性。在这两篇贡献中的第一篇中，我们概述了正在考虑的用于有效地将微米和纳米流体与集成光学相结合的不同的波导类型。大量的方法分为传统的折射率导波导波导和使用波干涉的最新实现。对每种类型的波导的基本原理和现状进行了描述。然后，我们重点回顾了最近在微细制作的液芯反共振反射光(ARROW)光波导方面的工作，包括相交2D波导网和平面光束几何形状的光学荧光和拉曼检测的发展。展示了用于电动操纵和分析单个生物颗粒的单分子检测能力和增加的电子控制。液芯箭头所展示的性能代表了集成波导用于超高灵敏度片上检测的潜力，并为下一代高性能、低成本和便携式生物医学仪器指明了方向。
We review recent developments and current status of liquid-core optical waveguides in optofluidics with emphasis on suitability for creating fully planar optofluidic labs-on-a-chip. In this first of two contributions, we give an overview of the different waveguide types that are being considered for effectively combining micro and nanofluidics with integrated optics. The large number of approaches is separated into conventional index-guided waveguides and more recent implementations using wave interference. The underlying principle for waveguiding and the current status are described for each type. We then focus on reviewing recent work on microfabricated liquid-core antiresonant reflecting optical (ARROW) waveguides, including the development of intersecting 2D waveguide networks and optical fluorescence and Raman detection with planar beam geometry. Single molecule detection capability and addition of electrical control for electrokinetic manipulation and analysis of single bioparticles are demonstrated. The demonstrated performance of liquid-core ARROWs is representative of the potential of integrated waveguides for on-chip detection with ultrahigh sensitivity, and points the way towards the next generation of high-performance, low-cost and portable biomedical instruments.