Coffee consumption and risk for type 2 diabetes mellitus
Coffee consumption and risk for type 2 diabetes mellitus
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DOI：
10.7326/0003-4819-140-1-200401060-00005
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发表时间：
2004-01-06
影响因子：
39.2
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
Salazar-Martinez, E;Willett, WC;Hu, FB
Background: in small, short-term studies, acute administration of caffeine decreases insulin sensitivity and impairs glucose tolerance.Objective: To examine the long-term relationship between consumption of coffee and other caffeinated beverages and incidence of type 2 diabetes mellitus.Design: Prospective cohort study.Setting: The Nurses' Health Study and Health Professionals' Follow-up Study.Participants: The authors followed 41934 men from 1986 to 1998 and 84 276 women from 1980 to 1998. These participants did not have diabetes, cancer, or cardiovascular disease at baseline.Measurements: Coffee consumption was assessed every 2 to 4 years through validated questionnaires.Results: The authors documented 1333 new cases of type 2 diabetes in men and 4085 new cases in women. The authors found an inverse association between coffee intake and type 2 diabetes after adjustment for age, body mass index, and other risk factors. The multivariate relative risks for diabetes according to regular coffee consumption categories (0,
