Structural Racism and Adverse Pregnancy Outcomes Through the Lens of the Maternal Microbiome.
Structural Racism and Adverse Pregnancy Outcomes Through the Lens of the Maternal Microbiome.
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DOI：
10.1097/aog.0000000000005345
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发表时间：
2023-10-01
影响因子：
7.2
通讯作者：
中科院分区：
文献类型：
--
作者：
一个人在美国的生活环境受到种族差异的影响，并影响微生物组和怀孕结果。微生物组科学通过根据个人的微生物特征表征健康和疾病状态，提供了个性化医疗的一瞥。如果不对使用种族作为变量进行批判性检查，微生物组研究可能会像其他基于种族主义生物学的科学领域一样容易陷入同样的陷阱。我们将研究种族作为妊娠相关微生物组研究中的生物变量的使用。来自调查怀孕期间肠道微生物组的研究的新数据表明，不良饮食对不良妊娠结局有很大影响。与不良妊娠结局有关的阴道微生物组的差异通常归因于种族。我们回顾了将系统性种族主义与妊娠健康结果差异联系起来的证据，重点关注阴道和肠道微生物组以及饮食。我们还审查了结构性种族主义如何最终导致社会经济地位较低的孕妇获得健康食品和更高风险环境暴露的不公平，并加剧了常见的妊娠合并症。
A person's lived environment in the United States is shaped by racial disparities and affects the microbiome and pregnancy outcomes. Microbiome science offers a glimpse into personalized medicine by characterizing health and disease states according to an individual's microbial signatures. Without a critical examination of the use of race as a variable, microbiome studies may be susceptible to the same pitfalls as other areas of science grounded in racist biology. We will examine the use of race as a biological variable in pregnancy-related microbiome research. Emerging data from studies that investigate the intestinal microbiome in pregnancy suggest strong influence of a poor diet on adverse pregnancy outcomes. Differences in the vaginal microbiome implicated in adverse pregnancy outcomes are frequently attributed to race. We review evidence that links systemic racism to pregnancy health outcome differences with a focus on the vaginal and intestinal microbiomes as well as diet. We also review how structural racism ultimately contributes to inequitable access to healthy food and higher risk environmental exposures among pregnant people of lower socioeconomic status and exacerbates common pregnancy comorbidities.
DOI：
10.1016/j.xagr.2022.100158
发表时间：
2023-02
期刊：
AJOG global reports
影响因子：
--
作者：
Peahl, Alex F;Rubin-Miller, Lily;Paterson, Victoria;Jahnke, Hannah R;Plough, Avery;Henrich, Natalie;Moss, Christa;Shah, Neel
通讯作者：
Shah, Neel
影响因子：
3.7
作者：
Grindler NM;Allshouse AA;Jungheim E;Powell TL;Jansson T;Polotsky AJ
通讯作者：
Polotsky AJ